Carbon nanoparticles neutralize carbon dioxide (CO) in cytotoxicity: Potent carbon emission induced resistance to anticancer nanomedicine and antibiotics.

Excessive carbon emissions, especially CO release, have been a global concern. Few studies applied nanotechnology to relieve the ecotoxicity of CO. Here, we applied carbon dots (CDs) to neutralize the CO.

Nano-evolution and protein-based enzymatic evolution predicts novel types of natural product nanozymes of traditional Chinese medicine: cases of herbzymes of Taishan-Huangjing () and Goji ().

Nanozymes and natural product-derived herbzymes have been identified in different types of enzymes simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozymes when synthesized remains elusive. An informed analysis might be useful for the prediction.

Honghua extract mediated potent inhibition of COVID-19 host cell pathways.

Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus.

Network pharmacology and experimental investigation of extract targeted kinase with herbzyme activity for potent drug delivery.

(Huangjing, RP) has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food. Here we investigated RP extract combination with kinase inhibitors in anti-cell growth and blockade in pathways targeting kinases. Experimental investigation and network pharmacology analysis were applied to test the potent kinase-mediated signaling.