Publications by authors named "Gulcin H Ozer"
Article Synopsis
- Richter's Transformation (RT) is a dangerous progression of chronic lymphocytic leukemia (CLL) that appears as diffuse large B-cell lymphoma, with a key role suspected for protein arginine methyltransferase 5 (PRMT5).
- Research shows that PRMT5 is consistently overexpressed in patients developing RT and that mice with increased levels of PRMT5 face a higher death risk and develop aggressive B-cell diseases similar to RT.
- The study also introduces PRT382, a new and selective inhibitor of PRMT5, suggesting its potential for targeted treatment in aggressive cases of CLL and RT, highlighting the need for clinical trials.
Role of lysine methylation of NF-κB in differential gene regulation.
Proc Natl Acad Sci U S A
August 2013
Lysine methylation of the p65 subunit of nuclear factor κB (NF-κB) on K218 and K221 together or K37 alone strongly enhances gene expression in response to cytokines. We analyzed the effects of K-to-Q mutations in the REL homology domain of p65 on the response to IL-1β in 293 cells with low levels of p65. The K218/221Q mutation greatly reduced the expression of 39 of 82 genes, whereas the K37Q mutation reduced the expression of 23 different genes.
View Article and Find Full Text PDFMicroRNAs (miRNAs) are small noncoding RNAs, 19-24 nucleotides in length, that regulate gene expression and are expressed aberrantly in most types of cancer. MiRNAs also have been detected in the blood of cancer patients and can serve as circulating biomarkers. It has been shown that secreted miRNAs within exosomes can be transferred from cell to cell and can regulate gene expression in the receiving cells by canonical binding to their target messenger RNAs.
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