Identification of IDH and TERTp mutations using dynamic susceptibility contrast MRI with deep learning in 162 gliomas.

Purpose: Isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase gene promoter (TERTp) mutations play crucial roles in glioma biology. Such genetic information is typically obtained invasively from excised tumor tissue; however, these mutations need to be identified preoperatively for better treatment planning. The relative cerebral blood volume (rCBV) information derived from dynamic susceptibility contrast MRI (DSC-MRI) has been demonstrated to correlate with tumor vascularity, functionality, and biology, and might provide some information about the genetic alterations in gliomas before surgery.

Spatio-temporal convolution for classification of alzheimer disease and mild cognitive impairment.

Background And Objective: Dementia refers to the loss of memory and other cognitive abilities. Alzheimer's disease (AD), which patients eventually die from, is the most common cause of dementia. In USA, %60 to %80 of dementia cases, are caused by AD.