Publications by authors named "Gul U"
Quinolone antibiotics are known for their antibacterial activity by inhibiting the enzyme DNA gyrase. Inspired by their mechanism, new compounds combining 1,4-dihydropyrimidine, a quinolone isostere, with pyridine/pyrimidine rings were synthesized. These derivatives showed antibacterial effects, likely through DNA gyrase inhibition, as supported by molecular docking and dynamics simulations.
View Article and Find Full Text PDFAutoinflammatory bone diseases (AIBDs) constitute a recently identified subset of autoinflammatory diseases. These conditions are characterized by an exaggerated inflammatory response in the bones without any apparent etiology. Inflammatory bone lesions associated with AIBDs exhibit chronic inflammation, are typically culture-negative, and do not exhibit discernible microorganisms on histopathological examination.
View Article and Find Full Text PDFPurpose: To investigate the effects of varicocelectomy on premature ejaculation (PE) in patients with varicocele and infertility.
Methods: A total of 82 sexually active patients aged 18 years or over who had undergone microscopic subinguinal varicocelectomy with a clinical diagnosis of varicocele in 14 urology clinics between October 2021 and March 2023 with primary infertility were evaluated prospectively Patients were evaluated using the Turkish validated form of the 'Premature Ejaculation Diagnostic Tool' (PEDT) scale. A PEDT score of 11 or above was taken to indicate the presence of PE.
Article Synopsis
- In aortic stenosis, the heart's left ventricle thickens, but after aortic valve replacement (AVR), it begins to reverse this hypertrophy, though the details of this process are not fully understood.
- A study involving 39 patients assessed changes in the heart's structure and function before and about 8 weeks after AVR, revealing a significant reduction in left ventricular mass primarily due to a decrease in the cellular component.
- After AVR, while the cellular area shrank more than the extracellular space, an increased extracellular volume fraction was linked to a decline in heart function, even though the method of surgery (surgical or transcatheter) didn't affect outcomes.
Familial Mediterranean fever (FMF) is the most prevalent monogenic autoinflammatory disorder, characterized by recurrent fever and serositis. It primarily affects individuals of Mediterranean descent, including Arabs, Armenians, Turks, and Jews. The Mediterranean fever (MEFV) gene, responsible for FMF, was discovered in 1997.
View Article and Find Full Text PDFNonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) associated with metabolic syndrome and increased cardiovascular risk. Resmetirom, a novel liver-directed selective thyroid hormone receptor-β (THR-β) agonist, has shown promise in addressing both hepatic and systemic lipid metabolism. This systematic review and meta-analysis aimed to evaluate the efficacy of resmetirom in improving cholesterol levels in NASH patients.
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- Pemphigus is a rare autoimmune condition causing blisters due to autoantibodies targeting desmoglein, impacting patient management by revealing gender differences in disease characteristics through a study comparing male and female patients.
- The study analyzed data from 1,218 pemphigus patients, finding that males experienced disease onset at an older age with more severe symptoms in specific body areas, while females had more mucosal manifestations, particularly in the gums.
- Overall, out of 44 examined variables, significant gender differences were noted in 9, highlighting the need for tailored and gender-specific treatment strategies for pemphigus.
Objective: To develop an efficient and easy-to-use nomogram that can predict testicular sperm extraction (TESE) success in men with non-obstructive azoospermia (NOA) by using pre-operative parameters.
Materials And Methods: Data of 3093 men who underwent TESE for NOA were included in this study. Demographic data, testis volumes, presence of varicocele, length of infertility, history of previous surgeries, history of genitourinary infections, smoking status, chromosome abnormalities, presence of Y-chromosome microdeletion, family history of infertility, testis biopsy, surgical data, sperm retrieval rate, final pathology obtained at TESE, follicle-stimulating hormone, luteinizing hormone, and testosterone levels were recorded.
Article Synopsis
- Type 2 diabetes (T2DM) increases the risk of cardiovascular diseases, prompting a study comparing the cardiovascular benefits of two medications, dapagliflozin and empagliflozin, known as SGLT2 inhibitors.
- A comprehensive analysis of twelve studies found that while dapagliflozin was better at preventing atrial fibrillation compared to empagliflozin, no significant differences were noted in other cardiovascular outcomes like major adverse events and mortality.
- Both medications were effective at reducing cardiovascular risks in T2DM patients, but dapagliflozin's lower atrial fibrillation risk could influence treatment choices, especially for at-risk individuals.
Article Synopsis
- - The study investigates the ECG characteristics of 103 acromegaly patients to assess the risk of cardiovascular complications and life expectancy, highlighting the significance of the Tp-e interval and its ratios as indicators of ventricular arrhythmia risk.
- - Results show that patients with both baseline and current ECGs experienced a decrease in heart rate, QRS duration, and several arrhythmia parameters, which were similarly affected regardless of whether the patients were in active or remission stages of the disease.
- - The conclusion emphasizes that treatment leads to improved ventricular arrhythmia parameters in acromegaly patients, which correlates with a significant reduction in IGF-1 levels, even in those with ongoing active disease.
Article Synopsis
- The study explores how different sexual positions impact ejaculation duration and the overall control of ejaculation, which is important for sexual pleasure.
- Conducted through an online survey with 1904 heterosexual men aged 18-65, it looked at factors related to premature ejaculation (PE) and how these men engage in various sexual positions.
- Results indicated a significant preference for doggy style across all groups, with non-PE participants more likely to change positions when close to ejaculation compared to PE participants, suggesting that adjusting sexual positions may help manage PE.
Background: The ongoing debate regarding the need for screening Cushing's syndrome (CS) in patients with obesity continues. The objectives of this study were to establish the prevalence of CS in the population with obesity and assess how metabolic health status influences cortisol levels following the 1 mg dexamethasone suppression test (DST).
Methods: This retrospective study included 1008 patients with obesity who underwent screening with the 1 mg DST for CS.
Objective: Increased frequency of autoimmune thyroid disease, particularly Hashimoto's thyroiditis (HT) was reported several studies in the literature, in individuals with childhood-onset systemic lupus erythematosus (cSLE). Our study aimed to investigate the prevalence and contributing factors of thyroid dysfunction and HT among cSLE patients.
Methods: Thyroid function tests were obtained cross-sectionally from cSLE patients.
Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease worldwide. In this retrospective cohort study, we aimed to assess the effects of various MEFV genotypes on the clinical characteristics of the patients, with a special focus on the joint involvement. In total, 782 patients with FMF were categorized into 3 groups according to the MEFV mutation; Group 1: Patients homozygous for M694V; Group 2: Patients carrying other pathogenic MEFV variants in exon 10 in homozygous or compound heterozygous states; and Group 3: FMF patients with other variants or without mutations.
View Article and Find Full Text PDFBackground: Countries designing a health benefit package (HBP) to support progress towards universal health coverage (UHC) require robust cost-effectiveness evidence. This paper reports on Pakistan's approach to assessing the applicability of global cost-effectiveness evidence to country context as part of a HBP design process.
Methods: A seven-step process was developed and implemented with Disease Control Priority 3 (DCP3) project partners to assess the applicability of global incremental cost-effectiveness ratios (ICERs) to Pakistan.
Article Synopsis
- - The study focused on understanding clinical features, treatments, and outcomes of children with type I interferonopathy, aiming to identify long-term morbidity or mortality predictors.
- - Out of 40 patients, most were diagnosed with Aicardi-Goutières syndrome and exhibited significant central nervous system involvement, with a notable percentage experiencing permanent morbidity or death during follow-up.
- - The presence of intracranial calcification on MRI was identified as a key predictor of poor outcomes, highlighting important insights into this rare condition.
Background: To demonstrate the long-term safety profile of canakinumab over a nine-year period by documenting adverse events in patients with various pediatric rheumatic diseases.
Research Design And Methods: This retrospective observational study was conducted at the Pediatric Rheumatology Department of Istanbul University Cerrahpasa between 2015 and 2023. The analysis concerned individuals who had been administered canakinumab treatment for at least six months.
Background And Purpose: Parents' views of nursing may play a key role in what kind of image their children hold of it. This study had three objectives. First, it investigated the image of nursing in the eyes of Generation Alpha and their parents.
View Article and Find Full Text PDFBackground: Given the strong genetic background of familial Mediterranean fever (FMF), the frequently reported co-existing diseases in children with FMF should also be investigated in other family members. Therefore, we aimed to examine the medical conditions of first-degree relatives (FDRs) of our pediatric patients with FMF in the present study.
Methods: Chronic diseases of FDRs of pediatric 449 FMF, 147 juvenile idiopathic arthritis (JIA) patients and 93 healthy controls (HC) were questioned during their routine clinical visits for 9 consecutive months.
Article Synopsis
- The study aimed to compare the success rates of sperm retrieval using microscopic testicular sperm extraction (mTESE) in men with non-obstructive azoospermia (NOA) who have either a solitary testis or bilateral testes.
- A total of 74 patients from each group were analyzed for factors like age, infertility duration, and hormonal levels, with a focus on FSH and LH, as well as testicular volume.
- Results showed similar sperm retrieval rates (54.1% for solitary and 56.76% for bilateral) but indicated higher levels of FSH and LH in those with a solitary testis; also, larger testicular size was linked to successful sperm retrieval in both groups.
In this study, a series of new benzimidazole-thiadiazole hybrids were synthesized, and the synthesized compounds were screened for their antimicrobial activities against eight species of pathogenic bacteria and three fungal species. Azithromycin, voriconazole, and fluconazole were used as reference drugs in the mtt assay. Among them, compounds and showed potent antifungal activity against with a MIC of 3.
View Article and Find Full Text PDFThe aim of this study was to investigate whether the histopathological findings of psoriasis varied by the biopsied lesion location. Age, gender, age at disease onset, lesion locations, presence or absence of a preliminary diagnosis of psoriasis, and histopathological findings of 307 patients were recorded. The sections prepared from the patients' paraffin blocks were reexamined microscopically, the severity of the observed findings was graded, and various histopathological features were recorded.
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- Non-obstructive azoospermia (NOA) is a prevalent and complex issue with varied treatment options and no definitive guidelines, leading to differing management practices internationally.
- A comprehensive survey with 336 responses from specialists in 49 countries explored current medical and surgical strategies for NOA, analyzing results against existing guidelines and offering expert recommendations.
- Key findings included diverse approaches to hormonal therapy, significant variation in sperm retrieval success rates, and differing protocols around varicocele repair and follicle-stimulating hormone cutoff levels for sperm retrieval.
Article Synopsis
- * Conducted from July to September 2022, a questionnaire gathered responses from 367 doctors in 49 countries, focusing on how they diagnose NOA through methods like hormone tests and genetic analyses.
- * The survey identified that while many practices align with guidelines, significant differences in approaches were found, underscoring the need for standardized, evidence-based international guidelines for NOA evaluation.