Publications by authors named "Gul Saeed"

Article Synopsis
  • Research indicates that structural and functional brain changes are linked to opioid use disorder (OUD), but earlier studies often had small participant groups, especially fewer women, and focused on single types of brain analysis.
  • This study aimed to use comprehensive brain imaging techniques, including T1-weighted MRI and resting-state fMRI, to better identify these brain alterations in OUD patients undergoing methadone treatment compared to healthy controls.
  • Results showed significant differences in brain volumes between the two groups, with OUD participants having smaller thalamus and temporal lobe sizes but larger brainstem and cerebellum volumes, and there were sex-based differences in the medial prefrontal cortex volumes.
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Article Synopsis
  • The study examined statin prescription rates and their impact on outcomes for atherosclerotic cardiovascular disease (ASCVD) in a large health care system, focusing on differences between Black and White patients.
  • Results showed that significantly fewer Black patients were prescribed statins compared to White patients, which was linked to increased ASCVD risks for both groups, though the race interaction was not a significant factor for ASCVD events.
  • Overall, the findings highlight that statins are underprescribed, and while disparities exist in prescription rates, they did not correlate directly with higher mortality risk among the studied populations.
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Objectives: Opioid use disorder (OUD) impacts millions of people worldwide. The prevalence and debilitating effects of OUD present a pressing need to understand its neural mechanisms to provide more targeted interventions. Prior studies have linked altered functioning in large-scale brain networks with clinical symptoms and outcomes in OUD.

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Background: Few studies have examined illness models among people with addiction. We investigated illness models and their associations with demographics and treatment beliefs among patients receiving methadone treatment for opioid use disorder.

Methods: From January 2019 to February 2020, patients receiving methadone treatment at outpatient opioid treatment programs provided demographics and rated using 1 to 7 Likert-type scales agreement with addiction illness models (brain disease model, chronic medical condition model [CMCM], and no explanation [NEM]) and treatment beliefs.

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To address information ambiguities, this study suggests using neutrosophic sets as a tactical tool. Three membership functions (called and ) that indicate an object's degree of truth, indeterminacy, and false membership constitute the neutrosophic set. It becomes clear that the neutrosophic connectivity index (CIN) is an essential tool for solving practical problems, especially those involving traffic network flow.

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Objective: To explore the care experiences of childbearing people with physical, sensory, and/or intellectual/developmental disabilities during pregnancy.

Design: Descriptive qualitative.

Setting: Ontario, Canada, where physician and midwifery care during pregnancy are provided at no direct cost to residents.

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Objectives: Corruption undermines the quality of healthcare and leads to inequitable access to essential health products. WHO, Global Fund, United Nations Development Programme (UNDP) and World Bank are engaged in anti-corruption in health sectors globally. Throughout the COVID-19 pandemic, weakened health systems and overlooked regulatory processes have increased corruption risks.

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Forward Osmosis (FO) is a promising separation technology with a wide range of applications in water and wastewater treatment. FO membrane is the core of the forward osmosis process. Recently, the organic membrane has been widely used for forward osmosis applications even though inorganic membrane has excellent mechanical properties, decent chemical resistance, high durability, high porosity, and good hydrophilicity.

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Corruption is a global wicked problem that threatens the achievement of health, social and economic development goals, including Sustainable Development Goal # 3: Ensuring healthy lives and promoting well-being for all. The COVID-19 pandemic and its resulting strain on health systems has heightened risks of corruption both generally and specifically within health systems. Over the past years, international organizations, including those instrumental to the global COVID-19 response, have increased efforts to address corruption within their operations and related programs.

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Introduction: The urgent need to acquire medical supplies amidst the COVID-19 pandemic has led to bypassing of controls that govern the global pharmaceutical supply chain, increasing the risk of corruption. Hence, promoting anti-corruption, transparency, and accountability (ACTA) in supply chain and procurement has never been more important. The adoption of digital tools, if designed and implemented appropriately, can reduce the risks of corruption.

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Background: Effective provider-patient communication is a key element of quality health care, including perinatal care. What constitutes "effective communication" in perinatal care may vary according to the population seeking care, such as women with intellectual and developmental disabilities (IDD) and sensory disabilities. Research broadly indicates that communication issues are among the barriers to perinatal care experienced by women with disabilities.

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Background: There is limited knowledge about the risk of non-alcoholic fatty liver disease (NAFLD) associated with cardiometabolic disorders in lean persons. This study examines the contribution of cardiometabolic disorders to NAFLD risk among lean individuals and compares to non-lean individuals.

Methods: We analyzed longitudinal data from 6,513 participants of a yearly voluntary routine health testing conducted at the Hospital Israelita Albert Einstein, Brazil.

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During the COVID-19 pandemic, outpatient psychotherapy transitioned to telemedicine. This study aimed to examine barriers and facilitators to resuming in-person psychotherapy with perinatal patients as the pandemic abates. We conducted focus group and individual interviews with a sample of perinatal participants ( = 23), psychotherapy providers ( = 28), and stakeholders ( = 18) from Canada and the U.

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Membranes with zeolites are encouraging for performing blood dialysis because zeolites can eliminate uremic toxins through molecular sieving. Although the addition of various pore-gen and adsorbent in the membrane can certainly impact the membrane production along with creatinine adsorption, however, it is not directed which pore-gen along with zeolite leads to better performance. The research was aimed at reducing the adsorption of protein-bound and uremic toxins by using mordenite zeolite as an adsorbent while polyethylene glycol and cellulose acetate as a pore generating agent.

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Objective: Atherosclerotic cardiovascular disease (ASCVD) and chronic obstructive pulmonary disease (COPD) are among the leading causes of morbidity, mortality, and economic burden in the United States (US). While previous reports have shown that an optimal cardiovascular risk factor (CRF) profile is associated with improved outcomes among COPD patients, the impact of ASCVD and CRF on healthcare costs and resource utilization is not well described.

Methods: The Medical Expenditure Panel Survey (MEPS) database was used from 2011 to 2016 to study healthcare expenditure for COPD patients with and without ASCVD and across CRF profiles in a nationally representative population of adults in the United States.

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Prior work suggests that Black patients have more severe obstructive sleep apnea (OSA) upon clinical presentation. However, the extent to which this may reflect differences in symptoms or other standard measures of OSA risk is unclear. We assessed for racial disparities in OSA characteristics at time of initial clinical diagnosis.

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Limited data suggest racial disparities in continuous positive airway pressure (CPAP) adherence exist. To assess whether CPAP adherence varies by neighborhood racial composition at a national scale. Telemonitoring data from a CPAP manufacturer database were used to assess adherence in adult patients initiating CPAP therapy between November 2015 and October 2018.

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