Trends in dental school faculty: An analysis of the results of the 2021‒2022 ADEA Dental School Faculty Demographic Census and 2018‒2019 ADEA Survey of Dental School Faculty.

Purpose/objectives: Each year, American Dental Education Association (ADEA) collects data on U.S. dental school faculty demographics, compensation, and vacant and lost positions.

The genomic landscape of 2,023 colorectal cancers.

Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive description of its genomic landscape is lacking. Here we perform whole-genome sequencing of 2,023 CRC samples from participants in the UK 100,000 Genomes Project, thereby providing a highly detailed somatic mutational landscape of this cancer. Integrated analyses identify more than 250 putative CRC driver genes, many not previously implicated in CRC or other cancers, including several recurrent changes outside the coding genome.

Evaluation of final-year nursing students' attitudes towards preventing medical device-related pressure ulcers using a ABC model of affect, behavior and cognitive dimensions.

Introduction: Half of the hospital-acquired pressure ulcers are associated with the use of medical devices. Nursing students provide care services to patients in clinical settings and intensive care units who have or are at risk for medical device-related pressure ulcers (MDRPUs). In the prevention and care of MDRPUs, the attitudes of nursing students towards preventing of pressure ulcers are as crucial as their knowledge level and clinical skills.

American Dental Education Association Compendium Entrustable Professional Activities Workgroup report.

Purpose: Entrustable professional activities (EPAs) are discrete clinical tasks that can be evaluated to help define readiness for independent practice in the health professions and are intended to increase trust in the dental graduate. EPAs provide a framework that bridges competencies to clinical practice. This report describes the work of the American Dental Education Association (ADEA) Compendium EPA Workgroup to develop a list of EPAs for dental education and supportive resources, including specifications and a glossary.

The 1000 Mitoses Project: A Consensus-Based International Collaborative Study on Mitotic Figures Classification.

The identification of mitotic figures is essential for the diagnosis, grading, and classification of various different tumors. Despite its importance, there is a paucity of literature reporting the consistency in interpreting mitotic figures among pathologists. This study leverages publicly accessible datasets and social media to recruit an international group of pathologists to score an image database of more than 1000 mitotic figures collectively.

Impact of climate change and land cover dynamics on nitrate transport to surface waters.

The study investigated the impact of climate and land cover change on water quality. The novel contribution of the study was to investigate the individual and combined impacts of climate and land cover change on water quality with high spatial and temporal resolution in a basin in Turkey. The global circulation model MPI-ESM-MR was dynamically downscaled to 10-km resolution under the RCP8.

Impact of HER2-Low Status in Metastatic Gastric Cancer: A Real-World Retrospective Cohort Study.

Introduction: Information regarding HER2-low tumors in metastatic gastric cancer is sparse. Our aim here was to determine the frequency of low HER2 expression in metastatic gastric cancer and to compare the clinicopathological characteristics, survival, and treatment response of HER2-low patients with HER2-zero patients.

Methods: The clinicopathological features, treatment responses, and survival of HER2-low tumors and HER2-zero tumors were compared.

Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility.

Background: The nucleosome assembly protein 1-like 1 (NAP1L1) is suggested to have an oncogenic role in several tumors based on its overexpression. However, its diagnostic and prognostic role in gastric cancer remains unclarified. This study aimed to evaluate the diagnostic and prognostic utility of NAP1L1 in gastric cancer patients.

How do biocidals affect the non-target marine organisms: the short-term effects of antifouling agent sodium pyrithione on Mediterranean mussels (Mytilus galloprovincialis, Lamark 1819).

The metallic pyrithiones are used as antifouling paints for marine vehicles against fouling organisms. However, they are dissolved in marine water and have negative impacts on marine non-target organisms. This study evaluated the adverse effects of sodium pyrithione (NaPT) on Mytilus galloprovincialis using total hemocyte counts (THCs), oxidative stress and antioxidant parameters, and histopathological observations.

Dentists of tomorrow 2023: An analysis of the results of the ADEA 2023 survey of U.S. Dental School Seniors.

Purpose/objectives: This study examines the journey of U.S. dental schools' predoctoral senior class of 2023, from the influences on and their motivations to pursue careers in dentistry, the aspects of their dental school experiences, plans upon graduation, and the investment in their careers.

Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Türkiye.

Objective: The present study was aimed at investigating the effects of anti-seizure medications (ASMs), patient demographic characteristics, and the seizure type and frequency on the development of congenital malformations (CMs) in the infants of pregnant women with epilepsy (PWWE).

Methods: PWWE followed up at the neurology outpatient clinic of 21 centers between 2014 and 2019 were included in this prospective study. The follow-up of PWWE was conducted using structured, general pregnant follow-up forms prepared by the Pregnancy and Epilepsy Study Committee.

Coarse-grained modeling of polystyrene-modified CNTs and their interactions with lipid bilayers.

In the present work, we describe Martini3 coarse-grained models of polystyrene and carboxyl-terminated polystyrene functionalized carbon nanotubes (CNTs) and investigate their interactions with lipid bilayers with and without cholesterol (CHOL) using molecular dynamics simulations. By changing the polystyrene chain length and grafting density at the end ring of the CNTs at two different nanotube concentrations, we observe the translocation of nanoparticles as well as changes in the lipid bilayer properties. Our results show that all developed models passively diffuse into the membranes without causing any damage to the membrane integrity, although high concentrations of CNTs induce structural and elastic changes in lipid bilayers.

The effect of interventions made in intensive care units to reduce alarms: A systematic review and meta-analysis study.

Objectives: This study examines the effects of the interventions in alarm management in intensive care units on reducing alarms on the basis of current evidence.

Methodology: This systematic review and meta-analysis study was conducted between January 1, 2010 and October 31, 2021 by searching 16 databases through an independent search by three researchers. The acronym of PICOS was used and the keywords as well as inclusion/exclusion criteria were determined.

Uncovering ecological regime shifts in the Sea of Marmara and reconsidering management strategies.

Ecosystem regime shifts can alter ecosystem services, affect human well-being, and trigger policy conflicts due to economic losses and reductions in societal and environmental benefits. Intensive anthropogenic activities make the Sea of Marmara ecosystem suffer from nearly all existing available types of ecosystem pressures such as biological degradation, exposure to hydrological processes, nutrient and organic matter enrichment, plastic pollution, ocean warming, resulting in deterioration of habitats. In this study, using an integrated ecosystem assessment, we investigated for the first time the historical development and ecosystem state of the Sea of Marmara.

Utilizing an organizational development framework as a road map for creating a technology-driven agile curriculum in predoctoral dental education.

The landscape of dental education is undergoing a paradigm shift from both the learner's and teacher's perspectives. Evolving technologies, including artificial intelligence, virtual reality, augmented reality, and mixed reality, are providing synergistic opportunities to create new and exciting educational platforms. The evolution of these platforms will likely play a significant role in dental education.

Polystyrene-modified carbon nanotubes: Promising carriers in targeted drug delivery.

To design drug-delivery agents for therapeutic and diagnostic applications, understanding the mechanisms by which covalently functionalized carbon nanotubes penetrate and interact with cell membranes is of great importance. Here, we report all-atom molecular dynamics results from polystyrene and carboxyl-terminated polystyrene-modified carbon nanotubes and show their translocation behavior across a model lipid bilayer together with their potential to deliver a molecule of the drug ibuprofen into the cell. Our results indicate that functionalized carbon nanotubes are internalized by the membrane in hundreds of nanoseconds and that drug loading increases the internalization speed further.

The effects of invasive epibiont Dreissena polymorpha on the narrow-clawed crayfish (Astacus leptodactylus, Astacidae) in Eğirdir Lake, Turkey: a case study.

In aquatic ecosystems, organisms are in a close relationship with each other. While this relationship is sometimes beneficial for both species, it can sometimes be harmful to one species. This study aimed to investigate the effects of colonized zebra mussels Dreissena polymorpha on the growth parameters and total hemocyte counts of the narrow-clawed crayfish Astacus leptodactylus from Eğirdir Lake (Turkey).

The occurrence and feeding of a critically endangered shark species, Oxynotus centrina in the Sea of Marmara.

The angular roughshark, Oxynotus centrina (Linnaeus, 1758), is a rarely encountered deep-sea demersal shark species. It is listed as "Critically Endangered" in the IUCN's regional assessment for the Mediterranean. Like other sharks and rays, the angular roughshark is subject to by-catch in demersal trawl and longline fisheries.

Ontogenetic shift in diet and trophic role of Raja clavata inferred by stable isotopes and stomach content analysis in the Sea of Marmara.

Trophic ecology studies on predator-prey interactions reveal insights into ecological communities and help understand a species' role in the food web by contributing to improved fisheries management and conservation capabilities. Understanding the ecological role of overexploited and endangered predators is essential to deciphering how their feeding behaviour influences food web dynamics. In this study, the authors investigated the feeding behaviour of the common and IUCN-listed Near Threatened (NT) thornback ray Raja clavata, using carbon and nitrogen stable isotope and stomach content analysis (SCA).

Expression Profile of Selected Antitumor Immune Response Genes in Pediatric Classic Hodgkin Lymphoma.

Classic Hodgkin lymphoma (cHL) is one of the most common pediatric solid tumors and is responsible for cancer-related deaths in children. Therefore, to modulate the active antitumor T-cell immune response in cHL can be a treatment strategy. In the present study, we aimed to investigate the expression profiles of selected antitumor immune response genes in pediatric cHL and their relationships with clinical and prognostic parameters to determine their significance in precision medicine.

Surgical Treatment in Refractory Epilepsy: Seizure Outcome Results Based on Invasive EEG Monitorization.

Aim: To discuss seizure outcomes of patients with invasive electroencephalography (EEG) monitorization (IEM) following their epilepsy surgery at our centre.

Material And Methods: Forty-seven patients suffering from refractory epilepsy and who were evaluated by invasive EEG were included in this retrospective study at Istanbul Faculty of Medicine from 2003 to 2017. We examined the Video EEG and invasive EEG monitorization, cranial MRI, SPECT, PET and neuropsychological tests of all patients.

HHV-8 and EBV Positive Lymphoproliferative Disease: A Challenging Case.

Human herpes virus-8 (HHV-8) is linked to four lymphoproliferative diseases: primary effusion lymphoma, HHV-8 positive multicentric Castleman disease (MCD), HHV-8 positive diffuse large B cell lymphoma and HHV-8 positive germinotropic lymphoproliferative disorder (GLPD). The diagnosis of HHV-8 associated lymphoproliferative diseases is quite challenging because each entity is rare and has a wide morphological spectrum. Our aim is to emphasize the overlapping histopathological features of MCD and GLPD as well as to underline the importance of clinicopathological correlation in case these two entities cannot be distinguished by pathological examination.