Unusual presentations of Carney Complex in patient with a novel PRKAR1A mutation.

Carney Complex (CNC) is a multiple neoplasia syndrome characterized by skin tumors and pigmented lesions, myxomas, and various endocrine tumors. The aim of this case report was to describe a case of CNC with a novel PRKAR1A mutation. A man aged 46 years with a medical history of surgery for cardiac myxomas at the age of 39 was admitted to our hospital because of four newly-developed heart masses.

The efficacy of microphototherapy with a MedLight CupCUBEGrimed device in psoriatic patients with localized lesions.

Background/aim: Psoriasis is a chronic skin disease. To reduce side effects associated with current treatment modalities, new treatment methods are required. Some clinicians have begun to use microphototherapy to treat psoriatic patients with a limited number of lesions (lesions affecting <10% of the body surface area).

Slowly Growing Nodule on the Trunk: Cutaneous Granular Cell Tumor.

Granular cell tumor (GCT) is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. The tumor mostly presents with a symptomatic slowly growing solitary nodule and overlying normal skin; therefore, it is not always considered in the differential diagnosis.

Multiple painful brownish plaques associated with local hyperhidrosis.

Eccrine angiomatous hamartoma is a rare hamartomatous lesion characterized by proliferation of eccrine glands and small blood vessels, and occasionally other elements. It generally arises congenitally or later in childhood, as solitary or multiple lesions on the distal extremities. Adult-onset multiple lesions are very rare.

Nevus-Associated versus de novo Melanoma: Do They Have Different Characteristics and Prognoses?

Aim: The aim of this study was to determine if nevus-associated melanoma differs in characteristics and prognosis from de novo melanoma.

Patients And Methods: The study included 118 melanoma patients. Clinical findings were retrospectively evaluated.

Comparison of growth hormone receptor, igf-1r and igfbp-3 between tumoral and non-tumoral areas in non-melanoma skin cancers.

Objective: A relationship between the pathogenesis of some cancers and growth hormone, insulin-like growth factor-1 and insulin-like growth factors binding protein-3 has been shown. Our aim was to evaluate the expression of growth hormone receptor, insulin-like growth factor-1 receptor and insulin-like growth factors binding protein-3 in actinic keratosis, basal cell carcinoma and squamous cell carcinoma, and to compare the expression patterns of tumoral areas with normal epidermis and skin appendages.

Material And Method: The formalin-fixed, paraff in-embedded tissues of 40 patients which were diagnosed as 15 actinic keratosis, 15 basal cell carcinoma and 15 squamous cell carcinoma were analyzed for growth hormone receptor, insulin-like growth factor-1 receptor and insulin-like growth factors binding protein-3 with the immunohistochemical method using the streptavidin-biotin-peroxidase technique.

Long-term follow-up of early mycosis fungoides patients treated with narrowband ultraviolet B phototherapy.

Background: Narrowband ultraviolet B (UVB) provides complete response (CR) in 54-91% of early mycosis fungoides (MF) patients. Data concerning relapse rate and relapse-free interval after discontinuation of therapy need clarification. The purpose of this study was to evaluate the relapse rate and the relapse-free intervals of early MF patients after achieving complete response with narrowband UVB phototherapy.

Plasma TM2-PK levels in mycosis fungoides patients.

Aerobic glycolysis increases in tumor cells and pyruvate kinase (PK) is one of the key enzymes involved; PK exists in different isoforms in various tissues. Tumor M2-PK (TM2-PK) is one of these isoforms and its expression has been observed in various tumor cells, including lymphocytes, and in lymphoproliferative disorders. The present study aimed to compare plasma levels of TM2-PK and serum levels of two established markers of various lymphoproliferative disorders-lactate dehydrogenase (LDH) and β-2 microglobulin, and to evaluate the role of TM2-PK in drug monitorization and disease activity in mycosis fungoides (MF) patients.

Clinical and histopathological response to acitretin therapy in lipoid proteinosis.

Lipoid proteinosis (LP) is a rare autosomal recessive genodermatosis associated with deposition of periodic acid-Shiff (PAS)-positive hyaline material in skin, mucosa, and other tissues. LP is caused by loss-of-function mutations in the extracellular matrix protein 1 gene (ECM1). No curative therapy is available.

Basal cell carcinoma arising in nevus sebaceous during childhood.

Nevus sebaceous usually occurs as a solitary lesion located mostly on the scalp and the face. The potential for nevus sebaceous to develop malignancy is well recognized, though it is generally thought that this transformation occurs only postpubertally or later. However, few cases of basal cell carcinoma arising in nevus sebaceous before puberty were reported.

The first reported case of lichen planus following inactivated influenza vaccination.

Lichen planus (LP) is an idiopathic, inflammatory, pruritic dermatosis of unknown origin. An increased prevalence of a wide range of diseases such as viral hepatitis C, hepatitis B, primary sclerosing cholangitis, and primary biliary cirrhosis have been associated with LP. Recently, LP has been reported following administration of different types of hepatis B vaccines but a relationship with an inactivated influenza vaccine (Fluarix, GlaxoSmithKline) has not been reported previously.

Multiple endocrine neoplasia type 2b associated with lichen nitidus.

Multiple endocrine neoplasia (MEN) type 2B syndrome is an autosomal dominantly inherited endocrine disorder with rare skin manifestations. We report the case of a 19-year-old Turkish girl who presented with skin-colored flat papules scattered all over the trunk and extremities. Additionally, she had marfanoid habitus, thick lips, and multiple flesh-colored papules over the inner eyelids and oral mucosa.

Effect of PUVA, narrow-band UVB and cyclosporin on inflammatory cells of the psoriatic plaque.

Background: Because antigen presenting is necessary for T-cell activation, antigen-presenting cells should be involved in the pathogenesis of psoriasis. In this study, our purpose was to evaluate and compare effects of PUVA, cyclosporine A and narrow-band UVB on dendritic cells and activated lymphocytes in the psoriatic lesions.

Methods: Forty-five volunteered patients (15 patients in each treatment group as PUVA, cyclosporin A and narrow-band UVB) were enrolled in this study.

In search of an optimum dose escalation for narrowband UVB phototherapy: is it time to quit 20% increments?

Objectives: Our aim was to compare 20% with 10% to 5% incremental regimens in narrowband UVB phototherapy.

Study Patients: The study included patients with psoriasis (N = 191) with Fitzpatrick skin phototypes II and III.

Results: Occurrence of erythema as well as maximum and cumulative doses were higher with 20% escalations, whereas response rates and time to response did not significantly differ.

Ectodermal dysplasia-skin fragility syndrome resulting from a new homozygous mutation, 888delC, in the desmosomal protein plakophilin 1.

We report an unusual case of an inherited disorder of the desmosomal protein plakophilin 1, resulting in ectodermal dysplasia-skin fragility syndrome. The affected 6-year-old boy had red skin at birth and subsequently developed skin fragility, progressive plantar keratoderma, nail dystrophy, and alopecia. Skin biopsy revealed widening of intercellular spaces in the epidermis and a reduced number of small, poorly formed desmosomes.

A case of lupus vulgaris successfully treated with antituberculous therapy despite negative PCR and culture.

A 14-year-old boy presented with a pink firm plaque with well-defined borders in the right infra-orbital skin area. On diascopy, the infiltrate exhibited a typical apple-jelly appearance. No acid-fast bacilli could be demonstrated.

Narrowband ultraviolet B phototherapy to clear and maintain clearance in patients with mycosis fungoides.

Background And Purpose: Narrowband ultraviolet B (UVB) phototherapy for early-stage mycosis fungoides (MF) has been found to be beneficial in some reports. Although rapid recurrences after discontinuation of therapy appear to interfere with its efficacy, optimal maintenance schedules for prolonged relapse-free intervals are not discussed in the literature. The purpose of this study was to review our experience with narrowband UVB in patients with MF.

Cutaneous silica granuloma: a lesion that might be clinically underdiagnosed.

Cutaneous silica granuloma is a poorly understood, uncommon condition. There have been relatively few reports of cutaneous silica granuloma despite the well-known ubiquitous nature of silica in the environment. The characteristic latency period between the time of silica exposure to the time of clinical onset of granuloma, lack of clear-cut histories of exposure in most cases and likelihood of spontaneous resolution, may challenge the diagnosis.

Interstitial granulomatous dermatitis with arthritis.

Interstitial granulomatous dermatitis with arthritis is an uncommon disorder. In its original description, the presence of linear inflammatory indurations on the lateral aspects of the trunk (the rope sign) in association with arthritis were considered the pathognomonic clinical features. Later cases presenting with plaques and papules have been reported.