Effect of Cypermethrin on Blood Hematology and Biochemical Parameters in Fresh Water Fish Ctenopharyngodon idella (Grass Carp).

The insecticide, cypermethrin, adversely affects biochemical parameters in blood and behavior in grass carp (Ctenopharyngodon idella). Fish were obtained from hatchery, reared in the laboratory. Different concentration of cypermethrin were applied.

Screening of potent phytochemical inhibitors against SARS-CoV-2 protease and its two Asian mutants.

Background: COVID-19, declared a pandemic in March 2020 by the World Health Organization is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The virus has already killed more than 2.3 million people worldwide.

Toxicity and bioaccumulation of manganese and chromium in different organs of common carp () fish.

The present research work was carried out to determine the bioaccumulation of manganese and chromium in the gills, intestine, muscles, skin and bones, as well as its acute toxicity and effects on hematological and biochemical parameters in Common carp (). Adult carps were exposed for 96 h to manganese sulphate and chromium chloride solution, a sub lethal concentration was used in the experiment. Bioaccumulation was highest in the gills followed by intestine > muscles > skin > bones.

Molecular Docking and Analysis of Fagonia Cretica and Berberis Lyceum Extracts Against Brucella Melitensis.

Background: Brucellosis is an economically important zoonotic disease caused by the Gram-negative bacteria belonging to the genus Brucella. Medicinal plants are well known for a wide variety of potential antimicrobial agents that can be used as antimicrobial drugs.

Methods: In the present study, crude ethanolic and methanolic extracts of local plants (Berberis lyceum and Fagonia cretica) were tested in vitro against Brucella melitensis via a well diffusion method for their antibacterial activity.

The Molecular Docking of Flavonoids Isolated from as a Dual Inhibitor of MDM2 and MDMX.

Background: Cancer is characterized by overexpression of p53 associated proteins, which down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein.

Objective: In the current, study in silico approaches were adapted to use a natural product as a source of cancer therapy.

In-silico Subtractive Proteomic Analysis Approach for Therapeutic Targets in MDR Salmonella enterica subsp. enterica serovar Typhi str. CT18.

Objective: In the present study, an attempt has been made for subtractive proteomic analysis approach for novel drug targets in Salmonella enterica subsp. enterica serover Typhi str.CT18 using computational tools.