Publications by authors named "Guk-Hyun Kim"

Red sea bream iridovirus (RSIV) occurs mainly at high water temperatures and infects more than 30 different species of fish. In Asia, infected fish cause mass mortality every year. Molecular diagnostics is a technology that efficiently detects and identifies a wide range of fish pathogens through rapid and sensitive analysis of their genetic material.

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Red seabream iridovirus (RSIV) is a major cause of marine fish mortality in Korea, with no effective vaccine available since its first occurrence in the 1990s. This study evaluated the efficacy of a formalin-killed vaccine against RSIV in rock bream under laboratory and field conditions. For the field trial, a total of 103,200 rock bream from two commercial marine cage-cultured farms in Southern Korea were vaccinated.

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Spring viremia of carp virus (SVCV) is a globally distributed virus that causes severe clinical symptoms and high mortality in fish belonging to the families Cyprinidae and Siluridae. To protect the host against viral infection, understanding the relatedness between viral susceptibility and antiviral mechanisms must be crucial. Thus, we evaluated the viral suppression efficacy of ribavirin by measuring the transcription levels of viral and immune genes in vitro.

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Article Synopsis
  • * This study developed and validated two diagnostic methods for KHV detection: a cross-priming amplification-based lateral flow assay (CPA-LFA) and a TaqMan probe-based real-time PCR.
  • * The CPA-LFA showed a sensitivity of 93.67% and a specificity of 100%, while the real-time PCR had both sensitivity and specificity at 100%, making both tests effective, with CPA-LFA being easier for quick tests outside the lab.
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Utilizing the near- to far-field transformation based on the 3-D finite difference time domain (FDTD) method and Fourier transformation, the far-field profile of a photonic crystal organic light emitting diode is studied to understand the viewing angle dependence. The measured far-field profiles agree well with those of the simulation. The enhancement of the extraction efficiency in excess of 60% is observed for the optimized photonic crystal pattern.

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Coupling characteristics between the single-cell hexapole mode and the triangular-lattice photonic crystal slab waveguide mode is studied by the finite-difference time-domain method. The single-cell hexapole mode has a high quality factor (Q) of 3.3Chi106 and a small modal volume of 1.

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We study whispering-gallery-like modes in photonic crystal air-bridge slab micro-cavities having H2 defects using finite-difference time-domain calculations. The defect geometry is optimized to increase the quality factor (Q) of the H2-cavity whispering-gallery mode (WGM). By symmetrically distributing 12 nearest neighbor holes around the defect and controlling size of holes, it is possible to drastically increase the Q of >10(5) while preserving effective mode volume of the order of the cubic wavelength in material.

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