Diurnal rhythm of human semen quality: analysis of large-scale human sperm bank data and timing-controlled laboratory study.

Study Question: Can we identify diurnal oscillations in human semen parameters as well as peak times of semen quality?

Summary Answer: Human semen parameters show substantial diurnal oscillation, with most parameters reaching a peak between 1100 and 1500 h.

What Is Known Already: A circadian clock appears to regulate different physiological functions in various organs, but it remains controversial whether diurnal rhythms occur in human semen parameters.

Study Design, Size, Duration: The medical record of a provincial human sperm bank (HSB) with 33 430 semen samples collected between 0800 and 1700 h from 1 March 2010 to 8 July 2015 was used to analyze variation in semen parameters among time points.

Poorer sleep quality correlated with mental health problems in college students: A longitudinal observational study among 686 males.

Objective: Poor sleep quality and mental health problems are common in college students. The objective of this study is to examine whether sleep quality predicts the risk of future mental health problems, and vice versa.

Methods: The sleep quality and mental health status of 686 male college students were estimated, and 582 of them were followed up a year later.

Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study.

Study Question: Is circadian desynchrony a risk factor of male reproductive damage in semen parameters and/or reproductive hormones?

Summary Answer: Circadian desynchrony correlates with decrease of sperm count, which was improved when circadian desynchrony was attenuated.

What Is Known Already: Circadian desynchrony caused by work (shift work) and non-work-related reasons is prevalent worldwide and has been found to be associated with decreased female fertility, but whether it harms male reproductive health is unclear.

Study Design, Size, Duration: A hybrid research was conducted.

MicroRNA-92a Targets SERTAD3 and Regulates the Growth, Invasion, and Migration of Prostate Cancer Cells via the P53 Pathway.

Background: The miR-17-92 cluster, consisting of six mature miRNAs including miR-17, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a, plays a key role in the tumorigenesis and development of various cancers. The dysregulation of the cluster correlates with the biological mechanism of tumor growth and metastasis in vivo. However, the relationship between miR-17-92 cluster and malignancy of prostate cancer remains unclear, and its regulatory mechanism is worth investigating for controlling the proliferation and invasion of prostate cancer.

Diurnal variation in sperm DNA fragmentation: analysis of 11,382 semen samples from two populations and animal experiments.

Circadian rhythms have been found in some reproductive functions phenotypes but remain unclear for sperm DNA fragmentation index (DFI). The present study aims to investigate the diurnal variation of DFI in mice model and men sperm. Adult male mice were sacrificed for sperm DFI with Sperm Chromatin Structure Assay (SCSA) in 24 hours at 6 evenly distributed time points.