Direct Fluoroacylation of Indole with Perfluoroalkyl Iodides.

Functionalization of perfluoroalkyl compounds has shown huge potential in synthetic chemistry and drug development. Herein, we report a one-pot tandem perfluoroalkylation-defluorination reaction of indole, perfluoroalkyl iodide, and water in the presence of NaSO. A wide array of indole derivatives were efficiently accessed with good yields under mild reaction conditions.

[On angiotensin II receptor distribution after myocardial infarction in dogs].

Objective: To investigate the effects of valsartan on expression of angiotensin II receptors in different regions of heart after myocardial infarction (MI).

Methods: Canines were divided into sham-operated control group (n=7), infarction group (n=7) and Valsartan group (10 mg x kg(-1) x day(-1) for 4 weeks after MI operation, n=7). Four weeks after operation, Doppler tissue imaging (DTI) was used to evaluate regional ventricular function in the noninfarcted myocardium (apical and basal near to the infarction region).

[Effect of chronic myocardial infarction on the distribution of beta-adrenoceptors in heart: experiment with dogs].

Objective: To investigate the distribution of beta-adrenoceptors at different sites of heart after myocardial infarction (MI).

Methods: 14 dogs were randomly divided into 2 equal groups: MI group, undergoing ligation of the left anterior descending coronary artery, and control group undergoing sham-operation. Four weeks later metoprolol, a beta 1-adrenergic receptor antagonist, was injected intravenously.

[Regional denervation after myocardial infarction and its effect on ventricular repolarization].

Objective: To investigate whether myocardial infarction (MI) causes heterogeneity of sympathetic innervation and to evaluate the effects of sympathetic stimulation on myocardial repolarization in the regions of denervation after MI.

Methods: Fourteen dogs were randomly divided into 2 equal groups: MI Group, undergoing ligation of the left anterior descending coronary artery, and Control Group, undergoing sham operation. Four weeks later thoracotomy was performed for the second time, the effective refractory period (ERP) of the non-infarcted myocardium at the base of heart proximal to the infarcted myocardium and the ERP of the non-infarcted myocardium at the cardiac apex distal to the infarcted myocardium by S(1)S(2) programmed stimulation.