Publications by authors named "Guiyuan Zeng"
Article Synopsis
- Human DNA topoisomerase I (Topo I) plays a crucial role in DNA regulation during processes like transcription and replication, making it a target for cancer treatments.
- A medicinal herb used in China for cancer treatment has yielded new compounds, including flavonoids and polyacetylenes, some of which show significant cytotoxic effects against human cancer cell lines.
- Certain flavonoids and polyacetylenes inhibit Topo I activity and cause cell cycle arrest in colon cancer cells, indicating that these flavonoids are likely key contributors to the herb's anti-tumor effects.
