Publications by authors named "Guiyou Wu"
Alzheimer's disease (AD) is a common neurodegenerative disease with pathological features including amyloid plaque deposits and neurofibrillary tangles. In this study, the expressions of miRNA, IGFBP-2 and neuronal ferritin were detected by qPCR, Western blot and immunohistochemistry. The regulatory effects of miRNA on IGFBP-2 and neuronal ferritin were further verified by intervention experiments with miRNA mimics and inhibitors.
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- - The study investigated the link between specific cuproptosis-related genes (CRGs) and Alzheimer's disease (AD) using bioinformatics and experimental methods, analyzing samples and developing a risk prediction model.
- - Analysis of human samples and animal models showed changes in the expression of key CRGs associated with AD, confirming findings through various validation techniques.
- - The research highlighted five CRGs as significant biomarkers for distinguishing AD patients from healthy individuals, aiding in the diagnosis and monitoring of the disease.
Purpose: The aim of our meta-analysis and systematic review was to contrast the positivity rates of [68Ga]Ga-FAPI PET and [18F]FDG PET in detecting bone and lymph node metastases across diverse cancer types.
Methods: We conducted a comprehensive search for eligible articles up until August 2023, utilizing databases including PubMed, Embase, and Web of Science. Studies focusing on the positivity rate of [68Ga]Ga-FAPI PET vs.
Objective: To compare the clinical efficacy of femoral head replacement and internal fixation in the treatment of unstable intertrochanteric fractures in the elderly.
Methods: Retrospective analysis of 70 cases of unstable intertrochanteric fractures treated from January 2016 to January 2019 and meeting the inclusion and exclusion criteria, 39 cases were fixed with closed reduction and new proximal femoral intramedullary nail(InterTAN), and 31 cases were treated with open trochanter reconstruction and artificial femoral head replacement. The operation time, intraoperative bleeding, hospital stay, weight bearing time, postoperative complication rate and hip function recovery (Harris score) were compared between two groups.
The lack of distinct morphological features of cryptic species is a hard problem for taxonomy, especially when the taxa are closely related with considerable amounts of ancestral polymorphism. Lately, intensive coalescent-based analyses involving multiple loci have become the preferred method to assess the extent of genetic distinctiveness in otherwise phenotypically similar populations. Previously, phylogenetic studies on Pachyhynobius shangchengensis uncovered five extremely deeply divergent clades, which suggested that this species may be a cryptic species complex.
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- Climate oscillations significantly impact species distribution and genetic variation, particularly for montane species like the Shangcheng stout salamander.
- Genetic analyses of 193 salamanders from six populations revealed high diversity and distinct evolutionary lineages, indicating long-term isolation and population expansion.
- Recent declines in two northern populations suggest they faced severe environmental pressures during the mid-Holocene, while ecological modeling shows historical climate changes affected their habitat suitability.
The complete mitochondrial genome of and implications for its taxonomy.
Mitochondrial DNA B Resour
October 2018
(Salamandridae, Urodela), collected from Yaoluoping Nature Reserve, was identified as a new species. The complete mitogenome sequence of is 16,259 by in length, including 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and D-loop region. The base composition of the mitogenome was 33.
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