Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of hook. f. and hance in the treatment of lung cancer.

Traditional Chinese medicine (TCM) usually acts in the form of compound prescriptions in the treatment of complex diseases. The herbs contained in each prescription have the dual nature of efficiency and toxicity due to their complex chemical component, and the principle of prescription is usually to increase efficiency and reduce toxicity. At present, the studies on prescriptions have mainly focused on the consideration of the material basis and possible mechanism of the action mode, but the quantitative research on the compatibility rule of increasing efficiency and reducing toxicity is still the tip of the iceberg.

A hillock-like phenomenon with low friction and adhesion on a graphene surface induced by relative sliding at the interface of graphene and the SiO substrate using an AFM tip.

Graphene demonstrates high potential as an atomically thin solid lubricant for sliding interfaces in industry. However, graphene as a coating material does not always exhibit strong adhesion to any substrates. When the adhesion of graphene to its substrate weakens, it remains unknown whether relative sliding at the interface exists and how the tribological properties of the graphene coating changes.

The Insertion Mechanism of a Living Cell Determined by the Stress Segmentation Effect of the Cell Membrane during the Tip-Cell Interaction.

Atomic force microscopy probes are proved to be powerful tools to measure and manipulate the individual cell, providing potential applications for the controlled drug/protein delivery. However, the measured insertion efficiency varies dramatically from 20 to 80%, in some cases, the nanotip can never penetrate the cell membrane no matter how much force is applied to it. Thus, the insertion mechanism of a living cell during the tip-cell interaction must be thoroughly investigated before this technology comes into practical applications.