F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution.

Fluorine (F) substitution is a common method of drug discovery and development. However, there are no accurate approaches available for predicting the bioactivity changes after F-substitution, as the effect of substitution on the interactions between compounds and proteins (CPI) remains a mystery. In this study, we constructed a data set with 111,168 pairs of fluorine-substituted and nonfluorine-substituted compounds.

Joint Under-Sampling Pattern and Dual-Domain Reconstruction for Accelerating Multi-Contrast MRI.

Multi-Contrast Magnetic Resonance Imaging (MCMRI) utilizes the short-time reference image to facilitate the reconstruction of the long-time target one, providing a new solution for fast MRI. Although various methods have been proposed, they still have certain limitations. 1) existing methods featuring the preset under-sampling patterns give rise to redundancy between multi-contrast images and limit their model performance; 2) most methods focus on the information in the image domain, prior knowledge in the k-space domain has not been fully explored; and 3) most networks are manually designed and lack certain physical interpretability.

Frequency Learning via Multi-Scale Fourier Transformer for MRI Reconstruction.

Since Magnetic Resonance Imaging (MRI) requires a long acquisition time, various methods were proposed to reduce the time, but they ignored the frequency information and non-local similarity, so that they failed to reconstruct images with a clear structure. In this article, we propose Frequency Learning via Multi-scale Fourier Transformer for MRI Reconstruction (FMTNet), which focuses on repairing the low-frequency and high-frequency information. Specifically, FMTNet is composed of a high-frequency learning branch (HFLB) and a low-frequency learning branch (LFLB).

FEGNet: A Feedback Enhancement Gate Network for Automatic Polyp Segmentation.

Regular colonoscopy is an effective way to prevent colorectal cancer by detecting colorectal polyps. Automatic polyp segmentation significantly aids clinicians in precisely locating polyp areas for further diagnosis. However, polyp segmentation is a challenge problem, since polyps appear in a variety of shapes, sizes and textures, and they tend to have ambiguous boundaries.

FrMLNet: Framelet-Based Multilevel Network for Pansharpening.

Most modern satellites can provide two types of images: 1) panchromatic (PAN) image and 2) multispectral (MS) image. The former has high spatial resolution and low spectral resolution, while the latter has high spectral resolution and low spatial resolution. To obtain images with both high spectral and spatial resolution, pansharpening has emerged to fuse the spatial information of the PAN image and the spectral information of the MS image.

Multilevel Edge Features Guided Network for Image Denoising.

Image denoising is a challenging inverse problem due to complex scenes and information loss. Recently, various methods have been considered to solve this problem by building a well-designed convolutional neural network (CNN) or introducing some hand-designed image priors. Different from previous works, we investigate a new framework for image denoising, which integrates edge detection, edge guidance, and image denoising into an end-to-end CNN model.

A Novel Retinex-Based Fractional-Order Variational Model for Images with Severely Low Light.

In this paper, we propose a novel Retinex-based fractional-order variational model for severely low-light images. The proposed method is more flexible in controlling the regularization extent than the existing integer-order regularization methods. Specifically, we decompose directly in the image domain and perform the fractional-order gradient total variation regularization on both the reflectance component and the illumination component to get more appropriate estimated results.

A Superpixel-Based Variational Model for Image Colorization.

Image colorization refers to a computer-assisted process that adds colors to grayscale images. It is a challenging task since there is usually no one-to-one correspondence between color and local texture. In this paper, we tackle this issue by exploiting weighted nonlocal self-similarity and local consistency constraints at the resolution of superpixels.

High-Quality Bayesian Pansharpening.

Pansharpening is a process of acquiring a multi-spectral image with high spatial resolution by fusing a low resolution multi-spectral image with a corresponding high resolution panchromatic image. In this paper, a new pansharpening method based on the Bayesian theory is proposed. The algorithm is mainly based on three assumptions: 1) the geometric information contained in the pan-sharpened image is coincident with that contained in the panchromatic image; 2) the pan-sharpened image and the original multi-spectral image should share the same spectral information; and 3) in each pan-sharpened image channel, the neighboring pixels not around the edges are similar.

Seed point discontinuity-based segmentation method for the substantia nigra and the red nucleus in quantitative susceptibility maps.

Background: The automatic segmentation of cerebral nuclei in the quantitative susceptibility mapping (QSM) images can provide assistance for surgical treatment and pathological mechanism studies. However, as the most frequently used segmentation method, the atlas method provides unsatisfactory results when segmenting the substantia nigra (SN) and the red nucleus (RN).

Purpose: To propose and evaluate an improved automatic method based on seed points-discontinuity for segmentations of the SN and the RN in QSM images.

Framelet-Based Sparse Unmixing of Hyperspectral Images.

Spectral unmixing aims at estimating the proportions (abundances) of pure spectrums (endmembers) in each mixed pixel of hyperspectral data. Recently, a semi-supervised approach, which takes the spectral library as prior knowledge, has been attracting much attention in unmixing. In this paper, we propose a new semi-supervised unmixing model, termed framelet-based sparse unmixing (FSU), which promotes the abundance sparsity in framelet domain and discriminates the approximation and detail components of hyperspectral data after framelet decomposition.

Effective identification and localization of immature precursors in bone marrow biopsy.

Abnormal localization of immature precursors (ALIP) aggregating and clustering in bone marrow biopsy appears earlier than that of bone marrow smears in detection of the relapse of acute myelocytic leukemia (AML). But traditional manual ALIP recognition has many shortcomings such as prone to false alarms, neglect of distribution law before three immature precursor cells gathered, and qualitative analysis instead of quantitative one. So, it is very important to develop a novel automatic method to identify and localize immature precursor cells for computer-aided diagnosis, to disclose their patterns before ALIP with the development of AML.

A variational approach for pan-sharpening.

Pan-sharpening is a process of acquiring a high resolution multispectral (MS) image by combining a low resolution MS image with a corresponding high resolution panchromatic (PAN) image. In this paper, we propose a new variational pan-sharpening method based on three basic assumptions: 1) the gradient of PAN image could be a linear combination of those of the pan-sharpened image bands; 2) the upsampled low resolution MS image could be a degraded form of the pan-sharpened image; and 3) the gradient in the spectrum direction of pan-sharpened image should be approximated to those of the upsampled low resolution MS image. An energy functional, whose minimizer is related to the best pan-sharpened result, is built based on these assumptions.