Two-in-one: Portable piezoelectric and plasmonic exciton effect-based co-enhanced photoelectrochemical biosensor for point-of-care testing of low-abundance cancer markers.

In-depth exploration of the local surface plasmon resonance and piezoelectric effects associated with metal can help develop efficient biosensors. Here, we presented for the first time the localized surface plasmon resonance (LSPR) and piezoelectric effects co-enhance the construction of an efficient intra-body phase electric field for the construction of efficient photoelectrochemical (PEC) biosensors. Briefly, the LSPR enhancement and piezoelectric enhancement effects between Ag nanoparticles and the piezoelectric material NaNbO were investigated in a PEC biosensor system under the excitation of portable UV light.

Manganese-phenolic network-coated black phosphorus nanosheets for theranostics combining magnetic resonance/photoacoustic dual-modal imaging and photothermal therapy.

In this work, we directly coated a layer of tannic acid (TA)-Mn2+ chelate networks on black phosphorus (BP) nanosheets (BPNSs) via a simple one-step method. The as-synthesized TA-Mn2+ chelate-coated BPNSs (BPNS@TA-Mn) have excellent T1 MRI contrast enhancement capability, good photoacoustic imaging performance, and high photothermal conversion efficiency, showing great potential in imaging-guided photothermal therapy.

Plant Polyphenol-Assisted Green Synthesis of Hollow CoPt Alloy Nanoparticles for Dual-Modality Imaging Guided Photothermal Therapy.

Theranostic nanomedicines that integrate diagnostic and therapeutic moieties into a single nanoscale platform are playing an increasingly important role in fighting cancer. Here, a facile and green synthetic strategy for hollow CoPt alloy nanoparticles (HCPA-NPs) using plant polyphenols as assisted agents is reported for the first time. This novel strategy enables size-controlled synthesis of HCPA-NPs through the control of the molecular sizes of polyphenols.

Invertase-labeling gold-dendrimer for in situ amplified detection mercury(II) with glucometer readout and thymine-Hg(2+)-thymine coordination chemistry.

A simple, low-cost transducer with glucometer readout was designed for sensitive detection of mercury(II) (Hg(2+)), coupling with thymine-Hg(2+)-thymine (T-Hg(2+)-T) coordination chemistry and invertase-functionalized gold-dendrimer nanospheres for the signal amplification. Initially, nanogold-encapsulated poly(amidoamine) dendrimers (Au DENs) were synthesized by in-situ reduction of gold(III). Thereafter, the as-prepared Au DENs were utilized for the labeling of invertase and T-rich signal DNA probe.

Hyperbranched rolling circle amplification based electrochemiluminescence aptasensor for ultrasensitive detection of thrombin.

An ultrasensitive electrochemiluminescence (ECL) aptamer sensor for protein (thrombin as an example) detection based on hyperbranched rolling circle amplification (HRCA) had been developed. A complementary single-strand DNA (CDNA) of the thrombin aptamer had been modified on the gold electrode firstly, and then hybridized with thrombin aptamer to make the aptamer immobilized on the electrode surface, in the presence of thrombin, aptamer-thrombin bioaffinity complexes formed and made thrombin aptamer leave the electrode surface. Thus, the linear padlock probe hybridized with the free CDNA on the electrode surface and circularized by Escherichia coli DNA ligase.