mechanistic study on mycophenolate mofetil drug interactions: effect of prednisone, cyclosporine, and others.

Objective: The metabolism- and transporter-based drug-drug interactions (DDIs) between mycophenolate mofetil (MMF) and co-administered medications may be key factors for the high individual variability in MMF exposure. This study systematically assessed the influence of co-medications on the mycophenolic acid (MPA) pharmacokinetic (PK) process , particularly to provide mechanistic evidence of the metabolic interaction among steroids, cyclosporine (CsA), and MMF.

Methods: Based on a previous study, we hypothesized that there are three main DDI pathways affecting MMF PK .