Publications by authors named "Guiter C"
Classical Hodgkin lymphoma and primary mediastinal B cell lymphoma (PMBCL) are related lymphomas sharing pathological, molecular and clinical characteristics. Here we discovered by whole-genome and whole-transcriptome sequencing recurrent somatic coding-sequence mutations in the PTPN1 gene. Mutations were found in 6 of 30 (20%) Hodgkin lymphoma cases, in 6 of 9 (67%) Hodgkin lymphoma-derived cell lines, in 17 of 77 (22%) PMBCL cases and in 1 of 3 (33%) PMBCL-derived cell lines, consisting of nonsense, missense and frameshift mutations.
View Article and Find Full Text PDFPrimary mediastinal B-cell lymphoma (PMBL) is a separate entity of aggressive B-cell lymphoma, characterized by a constitutive activation of janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway, also observed in Hodgkin lymphoma. Although many cancers exhibit constitutive JAK-STAT pathway activation, mutations of STAT genes have not been reported in neoplasms. Here, we show that MedB-1 PMBL-derived and L1236 Hodgkin-derived cell lines and 20 of 55 (36%) PMBL cases harbor heterozygous missense mutations in STAT6 DNA binding domain, whereas no mutation was found in 25 diffuse large B-cell lymphoma samples.
View Article and Find Full Text PDFArticle Synopsis
- Interleukin-4-induced gene 1 (IL4I1) is significant in B-cell lymphomas and exhibits distinct biochemical properties when expressed in HEK293 cells, where it is secreted into the culture medium.
- In analysis of lymphoid organs, IL4I1 was found to affect germinal center macrophages and was highly active in mature dendritic cells, indicating its potential role in immune responses.
- The enzyme inhibits the proliferation of T lymphocytes, particularly memory T cells, through its enzymatic activity and the production of H(2)O(2), suggesting IL4I1's function as an immunomodulatory factor.
Primary mediastinal large B-cell lymphoma (PMBL), currently recognized as a diffuse large B-cell lymphoma (DLBCL) subtype, shows increased expression of interleukin 4 (IL-4)/IL-13 signaling effectors and targets, suggesting constitutive activation of these pathways. We therefore investigated the functional state of the signal transducer and activator of transcription 6 (STAT6), mediating IL-4/IL-13 transcriptional effects. Constitutive STAT6 phosphorylation and DNA-binding activity were detected in PMBL cell lines but not DLBCL cell lines.
View Article and Find Full Text PDFA study has been made of over 3800 children to determine the preventive measures and the possible prophylaxy of accidents by children. The traumatological emergencies are concerned. The study shows, by means of histograms, an increase of their frequency not withstanding the security measures which have been taken.
View Article and Find Full Text PDF