Publications by authors named "Guiseppe Zaccai"
Biochemistry
September 2007
Article Synopsis
- The phosphoprotein (P) is crucial for the replication of rabies virus (RV) and vesicular stomatitis virus (VSV), and its oligomerization, potentially modulated by phosphorylation, is vital for its functionality.
- Recent studies using size exclusion chromatography and multiangle laser light scattering demonstrate that both unphosphorylated VSV and RV phosphoproteins primarily exist as dimers in solution, which are asymmetric and have specific hydrodynamic properties.
- Further experiments show that a mutant form of VSV phosphoprotein, designed to mimic phosphorylation, also forms a dimer with similar characteristics, but prolonged incubation at elevated temperatures can lead to the formation of irregular filamentous structures for both wild type and mutant proteins
