Effectiveness, safety and pharmacokinetics of Polo-like kinase 1 inhibitors in tumor therapy: A systematic review and meta-analysis.

Objective: To provide a systematic review of existing meta-analysis on the efficacy, safety and pharmacokinetics of the novel Polo-like kinase-1 (Plk1) inhibitors in various tumor treatments, and assess the methodological quality and the strength of evidence of the included meta-analysis.

Methods: The Medline, PubMed, Embase, etc. were searched and updated on 30 June 2022.

Progress in advanced nanotherapeutics for enhanced photodynamic immunotherapy of tumor.

Clinically, the conventional treatments of cancer are still often accompanied by tumor recurrence, metastasis and other poor prognosis. Nowadays, more attention has been paid to photodynamic therapy (PDT), which is regarded as an adjuvant antineoplastic strategy with superiorities in great spatiotemporal selectivity and minimal invasiveness. In addition to eliminating tumor cells via reactive oxygen species (ROS), more meaningfully, this phototherapy can trigger immunogenic cell death (ICD) that plays a vital role in photodynamic immunotherapy (PDIT).

Global dynamics of an SIRS epidemic model with saturation incidence.

In this paper, the dynamical behavior of an SIRS epidemic model with birth pulse, pulse vaccination, and saturation incidence is studied. By using a discrete map, the existence and stability of the infection-free periodic solution and the endemic periodic solution are investigated. The conditions required for the existence of supercritical bifurcation are derived.

Periodic solutions and bifurcation in an epidemic model with birth pulses.

The dynamical behavior of an epidemic model with birth pulses and a varying population is discussed analytically and numerically. This paper investigates the existence and stability of the infection-free periodic solution and the endemic periodic solution. By using discrete maps, the center manifold theorem, and the bifurcation theorem, the conditions of existence for bifurcation of the positive periodic solution are derived.

Algorithm-based qualitative and semiquantitative identification of prevalent vertebral fracture: agreement between different readers, imaging modalities, and diagnostic approaches.

Unlabelled: We compared SQ and ABQ diagnosis of VF imaged by radiography and X-ray absorptiometry. Mild ABQ VF had stronger associations with osteoporosis than mild SQ VF. Interobserver agreement (radiographic diagnosis) was better for ABQ.

Comparison of densitometric and radiographic vertebral fracture assessment using the algorithm-based qualitative (ABQ) method in postmenopausal women at low and high risk of fracture.

Unlabelled: Using ABQ diagnosis, the sensitivity to detect VF of densitometric versus radiographic assessment in 755 postmenopausal women was 71-81% and specificity was 97%. Misdiagnosis was influenced by image quality and was more common for mild deformities.

Introduction: Using densitometric vertebral fracture assessment (VFA), prevalent fractures are identified when vertebral height appears reduced by >or=20%.

Risk factors for vertebral and nonvertebral fracture over 10 years: a population-based study in women.

Unlabelled: Risk factors may vary for different types of fracture, in particular for vertebral fractures. We followed 367 women >50 yr of age from a population-based cohort for up to 10 yr. Factors that predicted vertebral rather than nonvertebral fractures related to physical weakness, poor health, and weight loss.

Identification of vertebral fracture and non-osteoporotic short vertebral height in men: the MrOS study.

Unlabelled: Non-osteoporotic SVH may mimic VF but is excluded in ABQ. In men, this led to discordance between ABQ and other methods, but SVH was not linked to low bone density. Exclusion of SVH could reduce false positives.

Impulsive ecological control of a stage-structured pest management system.

The dynamics of a stage-structured pest management system is studied by means of autonomous piecewise linear systems with impulses governed by state feedback control. The sufficient conditions of existence and stability of periodic solutions are obtained by means of the sequence convergence rule and the analogue of the Poincare criterion. The attractive region of periodic solutions is investigated theoretically by qualitative analysis.