A fault diagnosis method for analog circuits based on EEMD-PSO-SVM.

Analog circuit is an crucial component of electronic equipment, and the ability to diagnose its fault state quickly and accurately is essential for ensuring the safety and reliability of these electronic equipment. This paper addresses the problems of low diagnostic accuracy and the difficulties associated with model parameter selection in traditional fault diagnosis methods, particularly when dealing with nonlinear and non-stationary fault signals. A fault diagnosis method for analog circuits is proposed, which utilizes Ensemble Empirical Mode Decomposition (EEMD) for features extraction, the Maximum Information Coefficient algorithm (MIC) for features selection, and Particle Swarm Optimization (PSO) for optimizing Support Vector Machine (SVM) classification.

Mining bone metastasis related key genes of prostate cancer from the STING pathway based on machine learning.

Background: Prostate cancer (PCa) is the second most prevalent malignant tumor in male, and bone metastasis occurs in about 70% of patients with advanced disease. The STING pathway, an innate immune signaling mechanism, has been shown to play a key role in tumorigenesis, metastasis, and cancerous bone pain. Hence, exploring regulatory mechanism of STING in PCa bone metastasis will bring novel opportunities for treating PCa bone metastasis.

Cerebral F-FDG PET/CT Metabolism as Diagnostic Signature for Central Nervous System Toxicity After Immune Checkpoint Blockade Cancer Treatment.

Our aim was to investigate probable biomarkers specific to immune-related central nervous system toxicity (CNST) in cancer patients treated with immune checkpoint inhibitors (ICI) by analysis of F-FDG PET/CT images. Cancer patients receiving ICI treatment were enrolled in a multicenter observational study that analyzed regional metabolic changes before and during CNST onset from January 2020 to February 2022. In 1:1 propensity score-matched pairs, the regional SUV of each bilateral brain lobe of CNST patients (CNST+) was compared with that of patients who had central nervous system infections (CNSIs) and patients without CNST or CNSI (CNST-).

Sustainable freshwater production using novel cascade solar still with phase change material, serpentine water path, and copper fins.

Heat losses in solar stills are high, which has led to a decrease in their thermal efficiency. Also, the production of these devices is limited to the presence of the sun, and their production stops during cloudy hours or at night. To solve these problems, in this experimental study, two cascade solar stills are examined under relatively similar conditions for sustainable freshwater production.

PTEN/AKT and Wnt/β-catenin signaling pathways regulate the proliferation of Lgr5+ cells in liver cancer.

The progression and spread of tumors are believed to be primarily caused by cancer stem cells (CSCs). Nevertheless, the task of focusing on CSCs for cancer treatment continues to be difficult. Lgr5, a G-protein-coupled receptor containing leucine-rich repeats, is highly expressed in different types of cancer and serves as a distinctive marker for cancer stem cells (CSCs).

A new ferroptosis-related genetic mutation risk model predicts the prognosis of skin cutaneous melanoma.

Ferroptosis is an iron-dependent cell death mode and closely linked to various cancers, including skin cutaneous melanoma (SKCM). Although attempts have been made to construct ferroptosis-related gene (FRG) signatures for predicting the prognosis of SKCM, the prognostic impact of ferroptosis-related genetic mutations in SKCM remains lacking. This study aims to develop a prediction model to explain the relationship between ferroptosis-related genetic mutations and clinical outcomes of SKCM patients and to explore the potential value of ferroptosis in SKCM treatment.

Single-cell analysis reveals distinct functional heterogeneity of CD34 cells in anagen wound and diabetic wound.

Wound healing is a complex biological process involving multiple cell types with their critical functions. The diabetic wounds show delayed wound healing, while the anagen wounds display accelerated wound closure. However, the mechanisms underlying the effect of cellular heterogeneity on wound healing are still unclear.

Anti-Aging Effect of the Stromal Vascular Fraction/Adipose-Derived Stem Cells in a Mouse Model of Skin Aging Induced by UVB Irradiation.

Adipose-derived stem cells(ADSCs) have been used for anti-photo-aging. But the purification of ADSCs requires amplification and culture, there is considerable risk of direct treatment for patients. Stromal vascular fraction(SVF) is a biologically and clinically interesting heterogeneous cell population contains ADSCs.

Clinical characteristics and risk factors for severe burns complicated by early acute kidney injury.

Background: Early acute kidney injury (AKI) is a frequent fatal complication of severely burned patients. Although significant progress has been made in fluid resuscitation, intensive care, and renal replacement therapy (RRT) technology in recent years, the incidence and mortality rate in severely burned patients with AKI remains considerable. This study aims to provide theoretical evidence for prevention and treatment by investigating the clinical characteristics and risk factors influencing the incidence and severity of early AKI in severely burned patients.

[Effects of "3414" fertilizer application on the yield of Fagopyrum cymosum].

Objective: To study the effects of different fertilizer applications on the yield of Fagopyrum cymosum and explore the hese scheme for getting the maximum yield on purple soil in the Chongqing-west.

Methods: Experiment with implementing plan of "3414"; The quality Assessment by the contents of bipoly-chrysanthemin; The data process program under the Excel 2003, SPSS 13.0, MatlaB 7.

Cloning and characterization of porcine NOBOX gene.

Newborn ovary homeobox gene (NOBOX) is an oocyte-specific homeobox gene that plays a critical role in early folliculogenesis and represents a candidate gene for nonsyndromic ovarian failure. We used in silico approach in combination with rapid amplification of cDNA ends (RACE) to clone the full-length cDNA of NOBOX (GenBank Accession No. FJ587509) from porcine oocytes.