Infection in Treg-Specific USP21 Knockout Mice.

The E3 deubiquitinating enzyme ubiquitin-specific proteolytic enzyme 21 (USP21) plays vital roles in physiological activities and is required for Treg-cell-mediated immune tolerance. Using a murine model infected with , we observed that there were more cercariae developed into adults and more eggs deposited in the livers of the USP21FOXP3 (KO) mice. However, immunohistochemistry showed that the degree of egg granuloma formation and liver fibrosis was reduced.

Identification of the C-terminal domain of Daxx acts as a potential regulator of intracellular cholesterol synthesis in HepG2 cells.

Daxx is a highly conserved nuclear transcriptional factor, which has been implicated in many nuclear processes including transcription and cell cycle regulation. Our previous study demonstrated Daxx also plays a role in regulation of intracellular cholesterol content. Daxx contains several domains that are essential for interaction with a growing number of proteins.