Iron porphyrin-catalyzed -trifluoroethylation of anilines with 2,2,2-trifluoroethylamine hydrochloride in aqueous solution.

An iron porphyrin-catalyzed -trifluoroethylation of anilines has been developed with 2,2,2-trifluoroethylamine hydrochloride as the fluorine source. This one-pot N-H insertion reaction is conducted cascade diazotization/-trifluoroethylation reactions. The developed transformation can afford a wide range of -trifluoroethylated anilines in good yields using readily available primary amines and secondary anilines as starting materials.