A rare co-existence of histiocytic necrotizing lymphadenitis with metastatic papillary thyroid carcinoma and review of the literature.

Histiocytic necrotizing lymphadenitis (HNL) is a benign, self-limiting disease that is rare clinically. The coexistence of HNL and tumor is rarer. We report a male patient who was preoperatively diagnosed with papillary thyroid carcinoma with cervical lymph nodes metastasis, and the postoperative pathological examination showed histiocytic necrotizing lymphadenitis combined with metastatic papillary thyroid carcinoma in the same single lymph node.

HepPar1 and GATA-3 Expression in Neuroendocrine Neoplasms: A Potential Trap for Pathologic Diagnosis.

Objective: To investigate the expression and clinical significance of HepPar1 and GATA-3 in neuroendocrine neoplasms (NENs).

Materials And Methods: The expression of HepPar1 and GATA-3 in 144 cases of NENs was detected using immunohistochemistry, and the relevant literature was reviewed.

Results: HepPar1 was localized in the cytoplasm, and the positive rate of HepPar1 was 6.

LncRNA SNHG22 promotes gastric cancer progression by regulating the miR-101-3p/e2f2 axis.

Gastric cancer (GC) still poses a significant threat to human life. Hence, there is an urgent need to understand the mechanism of GC progression and develop novel therapeutics approach to treating GC. This study was conducted to evaluate the role of the lncRNA SNHG22 in the progression of GC.

LINC01232 Promotes Gastric Cancer Proliferation through Interacting with EZH2 to Inhibit the Transcription of KLF2.

To clarify the role of long intergenic nonprotein-coding RNA 1232 (LINC01232) in the progression of gastric cancer and the potential mechanism, we analyzed the expression of LINC01232 in TCGA database using the GEPIA online tool, and the LINC01232 level in gastric cancer cell lines was detected by quantitative real time-polymerase chain reaction (qRT-PCR) as well. Cell proliferation assay, colony formation assay, transwell assay and tumor formation experiment in nude mice were conducted to observe the biological behavior changes of gastric cancer cells through the influence of LINC01232 knockdown. LncATLAS database and subcellular isolation assay were used for subcellular distribution of LINC01232 in gastric cancer cells.

CypB promotes cell proliferation and metastasis in endometrial carcinoma.

Background: The molecular pathogenesis of endometrial cancer is not completely understood. CypB upregulated in many cancers, however, its role in endometrial carcinoma has not been studied. Here, we determine the effect of CypB on the growth of endometrial cancer.

What can we learn from a COVID-19 lung biopsy?

We report the case of a patient diagnosed with severe pneumonia due to coronavirus disease 2019 (COVID-19). A percutaneous lung biopsy was performed under ultrasound guidance. Morphological and ultrastructural characteristics of the patient's lungs are presented, along with details of some important changes in inflammatory biological markers, in order to help better understand the disease and provide clues to allow members of the multidisciplinary team to save more people.

High-grade serous carcinoma of fallopian tube with yolk sac tumor differentiation in a postmenopausal patient.

Yolk sac tumors (YSTs) are the second most common germ cell malignancy of the ovaries, generally presenting in children and young women. However, they rarely occur in the fallopian tubes of postmenopausal patients. The current rare case is composed of yolk sac tumor differentiation within high-grade serous carcinoma (HGSC) arising in the fallopian tube of a 68-year-old woman.

Chondroid gastrointestinal stromal tumor in the stomach with early adenocarcinoma.

Objective: To explore the pathologic features of gastric chondroid gastrointestinal stromal tumors.

Methods: The clinicopathologic data of one case of gastric chondroid gastrointestinal stromal tumor were collected and the features were analyzed by literature review.

Results: The male patient was 64 years old and had suffered from upper abdominal fullness discomfort without obvious cause for 5 years.

Nasal NK/T cell lymphoma mimicking mucosa-associated lymphoid tissue lymphoma in morphology: A case report.

The objective of the present study was to describe the clinicopathological features of a patient with nasal NK/T cell lymphoma that was similar in morphology to mucosa-associated lymphoid tissue lymphoma (MALToma). The clinicopathological data of a patient diagnosed with nasal NK/T cell lymphoma mimicking MALToma was collected, and the clinicopathological characteristics were discussed. The female patient was 43 years old and had suffered from persistent congestion for ten days.

Predictive value of single-nucleotide polymorphism signature for recurrence in localised renal cell carcinoma: a retrospective analysis and multicentre validation study.

Background: Identification of high-risk localised renal cell carcinoma is key for the selection of patients for adjuvant treatment who are at truly higher risk of reccurrence. We developed a classifier based on single-nucleotide polymorphisms (SNPs) to improve the predictive accuracy for renal cell carcinoma recurrence and investigated whether intratumour heterogeneity affected the precision of the classifier.

Methods: In this retrospective analysis and multicentre validation study, we used paraffin-embedded specimens from the training set of 227 patients from Sun Yat-sen University (Guangzhou, Guangdong, China) with localised clear cell renal cell carcinoma to examine 44 potential recurrence-associated SNPs, which were identified by exploratory bioinformatics analyses of a genome-wide association study from The Cancer Genome Atlas (TCGA) Kidney Renal Clear Cell Carcinoma (KIRC) dataset (n=114, 906 600 SNPs).

Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway.

Background: Drug resistance is common in cancer chemotherapy. This study investigates the role of Glycerol kinase 5 (GK5) in mediating gefitinib resistance in NSCLC.

Methods: The exosomal mRNA of GK5 was detected using a tethered cationic lipoplex nanoparticle (TCLN) biochip.

Study of differential gene expression between invasive multifocal/ multicentric and unifocal breast cancer.

Purpose: To investigate the differential gene expression pattern between invasive multifocal/multicentric (MMBC) and unifocal breast cancer (UFBC) with cDNA array and to discover the potential outlier genes associated with the incidence of MMBC and also to provide a guidance for clinical treatment and prognosis prediction.

Methods: This retrospective study analyzed the gene expression pattern alteration in breast cancer. We collected 156 MMBC (136 cases with 2 foci, 20 cases with 3 foci) and 130 UFBC samples from patients hospitalized in Yuhuangding Hospital, Yantai, from January 2005 to December 2015.

Multifocal and Multicentric Breast Carcinoma: A Significantly More Aggressive Tumor than Unifocal Breast Cancer.

Background/aim: There are still many questions that surround multifocal or multicentric breast carcinoma (MMBC). The aim of this study was to analyze the clinicopathological characteristics of MMBC and provide feasible suggestions for therapy.

Patients And Methods: A total of 156 cases of MMBC in 3,597 invasive ductal breast carcinomas were collected and reviewed.

Analysis of Clinicopathological Features and Prognostic Factors in 39 Cases of Bladder Neuroendocrine Carcinoma.

Aim: Through analysis and summarization of clinicopathological features, immunohistochemical expression, pathological diagnostic criteria, prognostic and other factors in patients suffering from bladder neuroendocrine carcinoma (BNEC), a better understanding of BNEC could be achieved to provide solid evidence for clinicopathology and prognosis.

Materials And Methods: The clinicopathological data of 39 cases of BNEC with up to 5-year follow-up data (median follow-up=650 days) were analyzed retrospectively based on immunohistochemical staining. Survival analyses were carried out using the Kaplan-Meier method and tested with the log-rank method.

Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression.

Primary carcinoid tumors are uncommon neoplasms in the kidney. The current study presents a case of primary carcinoid tumor of the kidney in a 49-year-old female who suffered from painless gross hematuria for half a month. Left hydronephrosis, a horseshoe kidney and a space-occupying lesion of the left ureter were found by abdominal computed tomography scans and ultrasonic testing.

Blastic plasmacytoid dendritic cell neoplasm presenting with a cutaneous tumor alone as the first symptom of onset: A case report and review of literature.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN), formerly named cluster of differentiation (CD)4/CD56 haematodermic neoplasm or blastic natural killer cell lymphoma, is a rare and highly aggressive haematopoietic malignancy. BPDCN typically occurs in the elderly, with a marked predilection for cutaneous involvement. The present study describes a case of BPDCN occurring in a 79-year-old male.

Primary clear cell adenocarcinoma of the colon presenting as a huge extracolic mass: A case report.

A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. The current study presents a case of such a tumor in the transverse colon of a 26-year-old male, and describes the computed tomography features of the neoplasm. The tumor appeared as an extensive extracolic mass, which displaced the loop of the small bowel and pancreas, and invaded the spleen.

Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature.

Squamous cell carcinoma is a common malignant tumor of the uterine cervix. The present study reports the case of squamous cell carcinoma of the uterine cervix with osteoclast-like giant cells (OGCs) in an 84-year-old female who had suffered from irregular vaginal bleeding for one month. Colposcopy was performed and a cauliflower-like mass was identified in the front lip of the uterine cervix.

Lipofibroadenoma of the thymus: a case report.

Unlabelled: We observed an unusual case of Lipofibroadenoma (LFA) in the anterior mediastinum with a 21-year-old man, who was detected with a mass on a chest X-ray scan for one month. Thymothymectomy was then performed and the mass was excised completely, in which the tumor was histologically composed of epithelial cells, lymphocytes, mature adipose and fibrous tissue. Within the tumor, the fat cells was distributed singly or multifocally under the ground of fibro tissue with hyaline degeneration, and the epithelial cells were arranged as crack structure with lymphocytes infiltrated sparsely.

Retroperitoneal composite pheochromocytoma-ganglioneuroma : a case report and review of literature.

Unlabelled: Composite pheochromocytoma/paraganglioma is a rare tumor with elements of pheochromocytoma/paraganglioma and neurogenic tumor. Most were located in the adrenal glands, and extra-adrenal composite pheochromocytoma is extremely rare. Only 4 cases in the retroperitoneum have been described in the online database PUBMED.

Composite lymphoma in the anterior mediastinum: a case report and review of the literature.

We recently encountered an unusual case of Composite lymphoma (CL) in the anterior mediastinum arising in a 37-year-old woman who presented initially with continuous pain in the right shoulder and chest. The woman had been suffered from continuous pain for three months before she went to our department of cardiovascular surgery. Chest computed tomography scan revealed the oval space-occupying lesion of anterior mediastinum.

Primary myoepithelial carcinoma of the larynx: case report and review of the literature.

Myoepithelial carcinoma of the head and neck is a rare malignant tumor and usually arises from the salivary glands. The larynx is an uncommon condition of involvement in myoepithelial carcinoma. Here we describe the forth reported case of myoepithelial carcinoma in the larynx.