Validation of ACC/AHA and ESC Sudden Cardiac Death Risk Guidelines in Diverse Hypertrophic Cardiomyopathy Cohort: Stratification HCM Study.

Background: Sudden cardiac death (SCD) is a major concern in patients with hypertrophic cardiomyopathy (HCM). The American College of Cardiology/American Heart Association (ACC/AHA) and the European Society of Cardiology (ESC) have different guidelines for SCD risk stratification. Their comparative performance in diverse populations remains uncertain.

Biosurfactants Used in the Bioremediation of Soils Contaminated With Hydrocarbons - Overview of the State of the Art and Future Perspectives.

Background: The increasing industrialization and hydrocarbon use have led to concerning soil contamination. Oil spills and improper disposal of oily waste pose threats to ecosystems and human health. The recovery of these environments is essential, but separating oily components from soil remains challenging.

Aquatic macrophytes as a source of antifouling non-toxic against bacterial biofilms and golden mussel attachment: a possible role of quorum-sensing interference.

Biofouling in freshwater and marine environments developed on man-made aquatic surfaces causes significant economic losses. Still, this problem is magnified when it comes to invasive species, such as the golden mussel. One of the alternatives to combat it is the use of antifouling solutions; however, the vast majority focus on solutions for the marine environment.

Ectopic expression of a truncated NLR gene from wild enhances resistance to .

causes devastating vascular wilt diseases in numerous crop species, resulting in substantial yield losses. The - (FOC) model system enables the identification of meaningful genotype-phenotype correlations and was applied in this study to evaluate the effects of overexpressing an NLR gene () from against pathogen infection. overexpression (OE) lines exhibited enhanced resistance to FOC without any discernible phenotype penalties.

Impacts of warming and acidification on pesticide toxicity in continental aquatic environments: A scientometric and systematic map.

Carbon dioxide emissions are altering aquatic ecosystems by causing water acidification and temperature increases, and these environments are also facing pesticide contamination. We present a scientometric and systematic map of these impacts in continental aquatic environments, aiming to provide an overview of research investigating the effects of temperature and acidification on pesticide toxicity. Our findings reveal a significant increase in research output on this topic, especially over the past seven years, with the United States leading due to high pesticide use and rigorous environmental monitoring.

Optimizing Surgical Outcomes: A Case Series on BREAST-V for Treating Breast Asymmetries.

Background: Breast asymmetry occurs when there is a discrepancy in the shape, volume, or positioning of the breasts. Various factors, including unequal development of breast buds, endocrine disorders, chest wall deformities, and surgical or posttraumatic sequelae, can contribute to this condition. Although breast asymmetry is common, clinically severe cases are rare and often require surgical correction because of potential postural, aesthetic, and psychological issues.

Laboratory profiles of patients hospitalized with COVID-19 pneumonia treated with tofacitinib or placebo: a post hoc analysis from the STOP-COVID trial.

Objective: Tofacitinib, an oral Janus kinase inhibitor, has been tested against a placebo in 289 patients with COVID-19 pneumonia. We analyzed the data from the tofacitinib- and placebo-treated patient cohorts to evaluate the laboratory profiles between baseline and day 7.

Methods: We performed post hoc analyses on the following laboratory tests over time during the first 7 days after randomization: hemoglobin, leukocytes, neutrophils, lymphocytes, platelets, alanine aminotransferase, and aspartate aminotransferase.

Intranasal liposomal angiotensin-(1-7) administration reduces inflammation and viral load in the lungs during SARS-CoV-2 infection in K18-hACE2 transgenic mice.

To effectively reduce the health impact of coronavirus disease (COVID-19), it is essential to adopt comprehensive strategies to protect individuals from severe acute respiratory syndrome. In that sense, much effort has been devoted to the discovery and repurposing of effective antiviral and anti-inflammatory molecules. The endogenous peptide angiotensin-(1-7) [Ang-(1-7)] has been recently proposed as a promising anti-inflammatory agent to control respiratory infections.

E3 Ubiquitin Ligase Smurf1 Regulates the Inflammatory Response in Macrophages and Attenuates Hepatic Damage during Betacoronavirus Infection.

The E3 ubiquitin ligase Smurf1 catalyzes the ubiquitination and proteasomal degradation of several protein substrates related to inflammatory responses and antiviral signaling. This study investigated the role of Smurf1 in modulating inflammation induced by Betacoronavirus infection. Bone marrow-derived macrophages (BMDMs) from C57BL/6 (wild-type) or Smurf1-deficient () mice were infected with MHV-A59 to evaluate the inflammatory response in vitro.

[Food consumption of the urban population in a municipality in the Legal Amazon, during climate events of flood and drought: a comparative study].

The aim of this study was to compare the food consumption of the population of Coari, Amazonas State, Brazil, according to the NOVA Classification, during the hydrological phases of drought and flooding of the Amazon rivers. An epidemiological, population-based, cross-sectional study was carried out. The sample consisted of 457 adult individuals.

Two new species and an updated key: Melastomateae from the Serra da Canastra National Park, Minas Gerais, Brazil.

Here we describe and illustrate and two new species of the Melastomateae tribe from Serra da Canastra National Park, Minas Gerais, Brazil. We also provide an updated identification key for the members of the tribe that occur in this Protected Area. has coriaceous leaves, broadly ovate to orbicular leaf blade, entire and adpressed-strigose margin, 11-17 basal acrodromous veins, and flowers with white petals.

The Hierarchical Coevolutionary Units of Ecological Networks.

In ecological networks, cohesive groups of species may shape the evolution of interactions, serving as coevolutionary units. Ranging across network scales, from motifs to isolated components, elucidating which cohesive groups are more determinant for coevolution remains a challenge in ecology. We address this challenge by integrating 376 empirical mutualistic and antagonistic networks and coevolutionary models.

Inferring the origin of new D-loop haplotypes of loggerhead sea turtles (Testudinata: Cheloniidae) from the Southwest Atlantic lineage.

The populations of the loggerhead turtles, present four main D-loop mitochondrial haplogroups that are distributed across the Indo-Pacific, Mediterranean, and Atlantic oceans. The Southwestern Atlantic (SWA) is one of the Regional Management Units (RMUs) of loggerheads, characterized by unique haplotypes, high nest density, and distinct life history traits. Detecting new D-loop haplogroups is important, particularly endemic ones, as they can enhance our understanding of their life history within the RMUs and contribute to the resolution of mixed stock analysis.

Brazilian children's quality of life during the COVID-19 pandemic: analysis of contextual factors and dimensions.

Objective: The aim of this study was to investigate the contextual factors associated with the quality of life (QOL) of Brazilian children aged 0-12 years during the strict period of social isolation.

Methods: This observational cross-sectional study was conducted between July and September 2020 using an online questionnaire on QOL-related family factors and the Pediatric Quality of Life Inventory (PedsQL™). Results were analyzed by multinomial logistic regression analysis.

Deep integration of low-cost liquid handling robots in an industrial pharmaceutical development environment.

The pharmaceutical industry is increasingly embracing laboratory automation to enhance experimental efficiency and operational resilience, particularly through the integration of automated liquid handlers (ALHs). This paper explores the integration of the low-cost Opentrons OT-2 liquid handling robot with F. Hoffmann-La Roche AG's in-house workflow orchestration software, AutoLab, to overcome barriers to lab automation.

Patterns and Risk Factors for Rehospitalizations Within the First 90 Days Following Discharge After Heart Transplantation.

Background: Heart transplantation (HT) recipients are at risk for urgent rehospitalizations following discharge. However, data on prevalence, risk factors and clinical outcomes associated with post-HT rehospitalization are limited.

Methods: This study aims to describe patterns of urgent rehospitalizations in HT recipients at a cardiology reference center in Brazil.

Tumor Neoepitope-Based Vaccines: A Scoping Review on Current Predictive Computational Strategies.

Therapeutic cancer vaccines have been considered in recent decades as important immunotherapeutic strategies capable of leading to tumor regression. In the development of these vaccines, the identification of neoepitopes plays a critical role, and different computational methods have been proposed and employed to direct and accelerate this process. In this context, this review identified and systematically analyzed the most recent studies published in the literature on the computational prediction of epitopes for the development of therapeutic vaccines, outlining critical steps, along with the associated program's strengths and limitations.

Prevalence of postoperative complications in oncologic gastro-esophageal surgeries: a cross-sectional study.

Purpose: This study evaluated the prevalence of complications in the postoperative period of esophagogastric oncological surgeries.

Methods: We conducted a retrospective cross-sectional study, adhering to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. The study size implied 163 patients who underwent surgical treatment for esophageal and gastric cancer and experienced postoperative complications between January 2018 and December 2022.