Black bean extract ameliorates liver fibrosis in rats with CCl4-induced injury.

Unlabelled: We assessed the anti-fibrotic effects of methanolic black bean extract antioxidants in a carbon tetrachloride (CCl4) liver injury model in rats. Experimentally intoxicated animals received CCl4 for eight weeks, the reference and test groups received daily intragastric quercetin or daily intragastric black bean extract. Liver fibrosis was assessed and quantified using morphometric analysis.

Ductular hyperplasia is characterized by an over expression of c-Myc in bile duct ligation + furan injured rats: possible role of interleukin-6.

The aim of this study was focused on the analysis of gene expression of pro- and anti-inflammatory cytokines, and c-Myc in liver carcinogenesis in bile duct ligation (BDL)+furan treated rats. We also correlated the molecular and immunohistochemical findings with the degree of architecture distortion and histopathological changes in the liver. Groups of rats were subjected to BDL and one week later, animals were given furan in corn oil by gavage at 45 mg/kg body weight, once a week, five times weekly, for 1--4 weeks.