Publications by authors named "Guillermo E Fernandez"
Kidney biopsies are used sparingly to diagnose kidney injury in the clinic. Here we have conducted a small exploratory study to directly compare the low-grade kidney injury monitoring performance of serum safety biomarkers, novel urine safety biomarkers, microscopic histopathology and targeted gene expression alterations in kidney biopsy specimens in rhesus monkeys treated with tobramycin. Targeted gene expression increases were observed in the kidney biopsy samples and whole kidney sections for kidney injury molecule 1 (), clusterin (), osteopontin () messenger RNA transcripts.
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- AMPK is an important protein that helps regulate energy in living things, but scientists still don’t fully understand it or how to use it for medicine.
- Researchers created a new drug called MK-8722 that activates AMPK in animals, which helps them take in sugar without needing insulin.
- This drug showed good results by improving blood sugar levels in test animals like monkeys, but it also caused some heart changes that didn’t seem to affect heart function.