Publications by authors named "Guillermo Aldama"
Ventricular fibrillation (VF) in acute myocardial infarction (AMI) is the main cause of deaths occurring in the acute phase of an ischemic event. Although it is known that genetics may play an important role in this pathology, the possible role of long non-coding RNAs (lncRNA) has never been studied. Therefore, the aim of this work is to study the expression of 10 lncRNAs in patients with and without VF in AMI.
View Article and Find Full Text PDFPrognosis after an acute myocardial infarction: survivor life expectancy.
Rev Esp Cardiol (Engl Ed)
October 2021
Article Synopsis
- The study examines how the COVID-19 outbreak affected the treatment and outcomes of patients with ST-segment elevation myocardial infarction (STEMI) in Spain, focusing on changes in patient care before and after the pandemic.
- Results showed a 27.6% decrease in STEMI patient treatments and a significant rise in in-hospital mortality during COVID-19 (7.5% vs 5.1%) despite consistent use of primary percutaneous coronary intervention as a treatment strategy.
- The findings indicate that COVID-19 led to longer ischemic times for patients and a notable incidence of confirmed SARS-CoV-2 infections during hospitalization, highlighting the challenges faced in managing STEMI cases during the pandemic.
Article Synopsis
- The study evaluated the impact of the COVID-19 outbreak on the treatment and outcomes of patients with STEMI in Spain, comparing cohorts treated before and after the pandemic began.
- It found a significant decrease in both suspected and confirmed STEMI patients, along with a longer ischemic time for those treated during COVID-19; however, the reperfusion strategy remained largely unchanged.
- In-hospital mortality increased during the COVID-19 period, with a reported rate rising from 5.1% to 7.5%, highlighting a concerning trend in patient outcomes despite consistent treatment methods.
Designs and methods for impact evaluation of interventions. Response.
Rev Esp Cardiol (Engl Ed)
August 2020
Article Synopsis
- - The study aimed to evaluate the impact of the PROGALIAM network on survival rates for ST-segment elevation myocardial infarction (STEMI) patients in northern Galicia from 2001 to 2013.
- - Researchers analyzed data from 6,783 STEMI patients, comparing outcomes before and after the implementation of PROGALIAM, finding that mortality rates were higher before its introduction and improved significantly afterwards.
- - Results indicated that PROGALIAM not only reduced overall mortality but also helped equalize survival outcomes across different regions, showing improved healthcare quality for STEMI patients in the area.
Article Synopsis
- Spontaneous self-terminating atrial fibrillation (AF) is a common heart rhythm issue, but the regulatory mechanisms are not well understood.
- A study analyzed the expression of microRNAs and transcription factors in pig heart samples during AF, revealing a significant reduction in factors like Pitx2, Tbx5, and Myocd with corresponding increases in specific miRNAs.
- The findings suggest that changes in miRNA levels and transcription factor expression play a crucial role in triggering AF, making them important for understanding the condition.
Background Aims: We evaluated the therapeutic potential of injection of in vitro differentiated bone marrow mesenchymal stromal cells (MSC) using a swine model.
Methods And Results: Myocardial infarction was induced by coronary occlusion. Three groups (n = 5 each) were analyzed: one group received an injection of 17.
Article Synopsis
- A neonate with complex congenital heart disease underwent a successful perventricular pulmonary valvuloplasty after surgery, guided only by echocardiography and without using fluoroscopy.
- The procedure demonstrates a new technique that can enhance patient safety and minimize radiation exposure.
- The report details both the procedure and its benefits, highlighting innovation in pediatric cardiac care.
A 72-year-old man presented with worsening shortness of breath and a systolic murmur. Transthoracic and transoesophageal echocardiograms revealed a huge mass (70 x 30 mm) obliterating the right ventricular outflow tract, with a peak transpulmonary gradient of 128 mmHg. Pathological examination confirmed the mass to be a primary cardiac rhabdomyosarcoma originating from the pulmonary valve.
View Article and Find Full Text PDFArticle Synopsis
- A study of 214 diabetes patients investigated the effectiveness of exercise echocardiography in predicting serious heart-related events over an average follow-up of about 44 months.
- During the follow-up period, there were 28 significant cardiac events, including 15 cardiac deaths and 13 myocardial infarctions.
- Key independent risk factors identified for predicting these events included insulin therapy, peak left ventricular ejection fraction, and ischemia detected through exercise echocardiography.
Article Synopsis
- A study analyzed left ventricular (LV) function in 99 studies by looking at global tissue Doppler velocity, strain rate, and strain.
- Significant correlations were found between LV ejection fraction and the assessed metrics: global tissue Doppler velocity (r = 0.50), strain (r = 0.63), and strain rate (r = 0.46), with all results being statistically significant (p <0.001).
- The findings suggest that these global assessments could be effective tools for evaluating LV function.
Background: The diagnosis of myocardial ischemia in patients with acute chest pain at rest but non-diagnostic electrocardiograms (ECG) is problematic. Ischemia Modified Albumin (IMA) is a new biochemical marker of ischemia, which may be useful to characterise acute coronary syndrome (ACS) patients.
Methods: We studied 131 patients (mean age 58.
Objectives: We sought to compare the feasibility and accuracy of peak and postexercise treadmill echocardiography with the use of continuous harmonic imaging capture.
Background: Previous work has demonstrated the superiority of peak exercise echocardiography (EE) as compared with post-EE for the diagnosis of coronary artery disease (CAD). However, most of these studies used fundamental imaging and view-per-view acquisition systems.
Article Synopsis
- Exercise echocardiography combined with atropine was tested on 31 patients who had a low likelihood of reaching a submaximal heart rate.
- The results showed that 77% of these patients were able to achieve conclusive test results using this method.
- This protocol may enhance the effectiveness of the exercise echocardiography procedure for specific patient groups.
Article Synopsis
- - Patients with cardiac syndrome X experience chest pain despite having normal coronary arteries, indicating various underlying mechanisms, including transient myocardial ischemia in some cases.
- - Endothelial dysfunction and microvascular abnormalities are crucial factors that may cause ischemia, with risk factors like hypertension and smoking potentially aggravating the issue, particularly in postmenopausal women.
- - While the overall prognosis for survival is good, the quality of life for these patients is often negatively impacted, making targeted management and understanding of individual symptoms essential for effective treatment.
Aims: We sought to assess (1) whether C-reactive protein (CRP) is an independent predictor of future cardiovascular events after adjustment for coronary artery disease (CAD) severity and (2) whether CRP levels correlate with number of angiographically complex coronary artery stenosis.
Methods And Results: We studied 825 consecutive angina patients (mean age 63+/-10 years, 74% men), 700 with chronic stable angina (CSA) and 125 with acute coronary syndromes without ST-segment elevation (ACS). The composite endpoint of non-fatal acute myocardial infarction, hospital admission with class IIIb unstable angina and cardiac death was assessed at one year follow-up.
Article Synopsis
- Ischemia-modified albumin (IMA) serves as a marker for myocardial ischemia, assessed through the albumin cobalt binding test.
- After elective cardioversion for atrial fibrillation, IMA concentrations were measured to check for signs of transient myocardial ischemia.
- Patients exhibiting electrocardiographic changes, like ST-depression or T-wave inversion, showed significantly higher IMA levels, indicating possible transient myocardial ischemia post-cardioversion.*
This study compared ischemia-modified albumin levels, a marker of ischemia in patients undergoing percutaneous coronary intervention. Ischemia-modified albumin levels were significantly lower in patients with collateral circulation compared with those without collateral circulation.
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