Publications by authors named "Guillermina Legaz"
Article Synopsis
- ET-1 and ET-3 reduce the activity of tyrosine hydroxylase (TH) in the anterior hypothalamus of rats through activation of ETB receptors, affecting norepinephrine release.
- The reduction in TH activity is specifically blocked by a selective ETB receptor antagonist but not by an ET(A) antagonist.
- The findings suggest that endothelins play a significant role in modulating norepinephrine neurotransmission via nitric oxide and guanosine pathways.
Based upon the existence of high density of ET-receptors on catecholaminergic neurons of the hypothalamus, we studied the effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on neuronal norepinephrine (NE) release in the rat posterior hypothalamus. The intracellular pathways and receptors involved were also investigated. Neuronal NE release was enhanced by ET-1 and ET-3 (10 etaM).
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