Nanoparticle-mediated photoporation - an emerging versatile physical drug delivery method.

Facilitating the delivery of impermeable molecules into cells stands as a pivotal step for both basic research and therapeutic delivery. While current methods predominantly use nanoparticles or viral vectors, the exploration of physical phenomena, particularly light-based techniques, remains relatively under-explored. Photoporation, a physical method, employs either pulsed or continuous wave lasers to create transient pores in cell membranes.

Laser-Assisted Delivery of Molecules in Fungal Cells.

Fungal infections are becoming a global health problem. A major limiting factor for the development of antifungals is the high impermeability of the rigid and thick fungal cell wall. Compared to mammalian cells, fungal cells are more resilient to perforation due to the presence of this carbohydrate armor.

Design of an optically-locked interferometer for attosecond pump-probe setups.

We present the design and performance of an active stabilization system for attosecond pump-probe setups based on a Mach-Zehnder interferometer configuration. The system employs a CW laser propagating coaxially with the pump and probe beams in the interferometer. The stabilization is achieved with a standalone feedback controller that adjusts the length of one of its arms to maintain a constant relative phase between the CW beams.