Publications by authors named "Guillaume Klausner"
Background: Assess the current and potential indications of photobiomodulation (PBM) therapy and their level of evidence in the prevention or treatment of side effects related to oncology treatments (radiation therapy, and to a minimal extent favored and hematopoietic stem cell transplants). And report on the recommended modalities (parameters and doses) of PBM therapy.
Materials And Methods: The Embase, Medline/PubMed, Cochrane, EBSCO, Scopus, and LILACS databases were systematically reviewed to include and analyze publications of clinical studies that evaluated PBM in the prevention or management side effects related to cancer treatments.
This review of the literature provides an overview of the combination of stereotactic radiotherapy (SBRT) with immune checkpoint inhibitors (ICI) and tyrosine kinase inhibitors (TKI) in oligo-progressive non-small cell lung neoplasia. This combination showed local control of 76-100% and distant response rates of 8-60%. They reported progression-free survival of 2.
View Article and Find Full Text PDFLeptomeningeal carcinomatosis (LC) is an unmet medical need associated with death in 4-6 weeks without treatment, delayed by 4 months in some patients with favorable prognosis and aggressive multimodal therapy. Unfortunately, most clinical trials excluded patients with LC, and the best management remains unknown. Here we present the first report of a LC secondary to HR positive breast cancer with a complete response to CDK4/6 inhibitors abemaciclib, letrozole and hippocampal-avoidance whole-brain radiotherapy.
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- * The study examines the effects of three normalization methods and two discretization methods on radiomics features in brain MRI, establishing guidelines for consistent future research.
- * Using two datasets, results demonstrate that proper intensity normalization significantly enhances the stability of extracted features, which can improve the accuracy of machine learning algorithms in classifying tumor grades.
Article Synopsis
- The study evaluates how various factors affect the quality of pseudo computed tomography (pCT) generated from magnetic resonance imaging (MRI) using a 3D convolutional neural network (CNN).
- It includes analysis of 402 brain tumor cases, examining different MRI sequences and standardization approaches, while also comparing two specific neural network architectures (HighResNet and 3D UNet).
- Results show that larger training datasets improve pCT quality, with the best pCTs produced from >200 samples, and reveal that specific standardization methods (like white stripe) yield lower errors compared to others.
Background: The objective of the study was to evaluate the outcomes in terms of efficacy and safety of a large consecutive series of 362 patients with renal cell carcinoma (RCC) brain metastases treated using stereotactic radiosurgery (SRS) in the tyrosine kinase inhibitor (TKI) era.
Patients And Methods: From 2005 to 2015, 362 consecutive patients with brain metastases from RCC were treated using SRS in 1 fraction: 226 metastases (61 patients) using Gamma-Knife at a median of 18 Gy (50% isodose line); 136 metastases (63 patients) using linear accelerator at a median of 16 Gy (70% isodose line). The median patient age was 58 years.
Head and neck squamous-cell carcinomas (HNSCCs) have a significant lymph node tropism. This varies considerably depending on the primary tumor site and the Human Papillomavirus (HPV) status of the disease. The best therapeutic option, between up-front lymph node dissection and chemoradiotherapy (CRT) +/- followed by lymph node dissection in case of persistent lymphadenopathy or regional relapse, remains unclear.
View Article and Find Full Text PDFThe best curative option for locally advanced (stages II-III) squamous-cell carcinomas of the anal canal (SCCAC) is concurrent chemo-radiotherapy delivering 36-45 Gy to the prophylactic planning target volume with an additional boost of 14-20 Gy to the gross tumor volume with or without a gap-period between these two sequences. Although 3-dimensional conformal radiotherapy led to suboptimal tumor coverage because of field junctions, this modality remains a standard of care. Recently, intensity-modulated radiotherapy (IMRT) techniques improved tumor coverage while decreasing doses delivered to organs at risk.
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- - Cervical lymphadenopathies of unknown primary account for 3% of head and neck cancers, and recent developments in diagnosis and treatment are reshaping their management.
- - Advances in imaging techniques like PET scans and the rise of minimally invasive surgical methods, such as robotic or laser approaches, have improved the detection of primary cancers associated with lymphadenopathies.
- - Over the past decade, the approach to treating these cases has evolved significantly, particularly influenced by factors like HPV-related cancers and adjustments in the TNM staging system, though the effectiveness of these changes still needs evaluation.
Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy that occurs with unpredictable chemosensitivity and limited treatment options in the advanced setting. Prognosis is poor, and exploring new treatment options for such diseases is difficult because of its rarity. Clinical activity of trabectedin for advanced DSRCT was scarcely reported in the literature.
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