Publications by authors named "Guillaume Jouvet"
Article Synopsis
- The study focused on understanding patient-ventilator asynchrony in critically ill children, highlighting significant issues with ventilator interactions and identifying key risk factors.
- Approximately 52 children were monitored, revealing that more than a quarter of their time on the ventilator was marked by asynchrony, which was mainly due to cycling-off errors and trigger delays.
- Despite documenting high levels of asynchrony, there was no clear link found between the severity of asynchrony and improved outcomes like ventilator-free days, indicating a need for better strategies in pediatric critical care.
Article Synopsis
- - This review highlights recent advancements in respiratory assistance, focusing on optimizing mechanical ventilation, implementing high-frequency oscillatory ventilation, and enhancing noninvasive ventilation techniques.
- - Emphasis is placed on preventing ventilator-induced lung injury and diaphragmatic dysfunction, which are critical to reducing patient mortality and ICU stay duration.
- - The review suggests that incorporating various physiological measurements can improve ventilator management and proposes forming a ventilation consortium to foster innovation and collaboration among companies, clinicians, and researchers.
Background: High-flow nasal cannula (HFNC) therapy is increasingly used in pediatric ICUs as an intermediate level of support between conventional oxygen delivery and noninvasive ventilation (NIV). The safety of HFNC has seldom been studied, and some cases of barotrauma have been reported. This retrospective study aims to describe HFNC use in a tertiary care pediatric ICU, with a focus on the complications associated with this therapy.
View Article and Find Full Text PDFIntroduction: The need for intubation after a noninvasive ventilation (NIV) failure is frequent in the pediatric intensive care unit (PICU). One reason is patient-ventilator asynchrony during NIV. Neurally adjusted ventilatory assist (NAVA) is a mode of ventilation controlled by the patient's neural respiratory drive.
View Article and Find Full Text PDFPurpose: Diaphragm function should be monitored in critically ill patients, as full ventilatory support rapidly induces diaphragm atrophy. Monitoring the electrical activity of the diaphragm (EAdi) may help assess the level of diaphragm activity, but such monitoring results are difficult to interpret because reference values are lacking. The aim of this study was to describe EAdi values in critically ill children during a stay in the pediatric intensive care unit (PICU), from the acute to recovery phases, and to assess the impact of ventilatory support on EAdi.
View Article and Find Full Text PDF1. Tryptophan hydroxylase (TPOH) is the first enzyme in the melatonin synthesis pathway and the rate-limiting enzyme in serotonin synthesis. We established in this study an in vitro model of ovine pinealocytes to investigate the role of TPOH in melatonin production.
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