Publications by authors named "Guillaume Fort"
Infectious alleles of endogenous banana streak viruses (eBSVs) are present in the genome of all banana interspecific cultivars, including plantains and cooking types. Activation of these infectious eBSV alleles by biotic and abiotic stresses leads to spontaneous infections by cognate viruses and raises concerns about their ability to promote outbreaks of banana streak viruses under field cultivation conditions. We undertook a comprehensive risk assessment study of infectious eBSV alleles of species BSOLV, BSGFV and BSIMV in banana interspecific cultivars in Guadeloupe, a tropical island of the Caribbean where bananas are grown for export and local markets.
View Article and Find Full Text PDFThe identification of the limits between the cell division, elongation and mature zones in the root apex is still a matter of controversy when methods based on cellular features, molecular markers or kinematics are compared while methods based on cell length profiles have been comparatively underexplored. Segmentation models were developed to identify developmental zones within a root apex on the basis of epidermal cell length profiles. Heteroscedastic piecewise linear models were estimated for maize lateral roots of various lengths of both wild type and two mutants affected in auxin signaling ( and ).
View Article and Find Full Text PDFBackground: The use of antipsychotics may increase the risk of endometrial cancer through elevation of prolactin levels. We investigated the association between antipsychotics that are known to cause prolactin elevation and the risk of endometrial cancer.
Methods: In data from the United Kingdom Clinical Practice Research Datalink, all women who were newly treated with antipsychotics from 1990-2013 were identified and followed until 2014.
Article Synopsis
- Comprehensive inventories of plant viral diversity are crucial for effective quarantine and sanitation efforts, especially since current detection methods like PCR are limited to known pathogens.
- Next generation sequencing (NGS) using virus-derived small interfering RNAs (siRNAs) and virion-associated nucleic acids (VANA) identified not only the expected Sugarcane streak Egypt Virus (SSEV) but also a new mastrevirus, named Sugarcane white streak Virus (SWSV), in quarantined sugarcane plants.
- The study highlights the advantages of NGS in detecting diverse viral infections that traditional methods might miss, suggesting it could significantly improve virus detection in plant quarantines.
Concurrent use of tamoxifen and cytochrome P450 2D6 (CYP2D6) inhibitors, such as selective serotonin reuptake inhibitors, has been shown to decrease plasma concentrations of tamoxifen metabolites. However, it is still unclear whether such concurrent use affects tamoxifen's effectiveness. Thus, the objective of this study is to determine whether concurrent use of tamoxifen with CYP2D6 inhibitors increases the risk of recurrence in patients newly diagnosed with breast cancer.
View Article and Find Full Text PDFBackground: In a real-life setting, differences across newer antidepressants in patterns of use remain poorly explored, particularly in the older patients despite the high prevalence of late-life depression.
Methods: An observational retrospective cohort study was conducted in the community-dwelling elderly population of Quebec using health databases to compare the newer antidepressants with respect to non-persistence, associated health care costs and cost/persistence ratio. A random sample of 12,825 outpatients who initiated an antidepressant treatment in 2000 were followed for 12 months.
Objective: To assess the effect of an interdisciplinary educational program in reducing the use of antipsychotics in nursing home residents with dementia.
Methods: We conducted a longitudinal pilot study to test the implementation of a 7-month interdisciplinary educational program in a fixed cohort of residents with dementia receiving antipsychotics. The program included consciousness-raising, educational sessions, and clinical follow-up.
Objective: Research in the United States tends to attribute low rates of use of mental health services by immigrants to economic barriers. The purpose of our study was to examine this issue in the context of Canada's universal health care system.
Methods: A survey of the catchment area of a comprehensive clinic in Montreal interviewed random samples of 924 Canadian-born individuals and 776 immigrants born in the Caribbean (n = 264), Vietnam (n = 234), or the Philippines (n = 278) to assess their health care use for somatic symptoms, psychological distress, and recent life events.
Objective: To investigate the prevalence, clinical correlates, and treatment of migraine in bipolar disorder.
Background: The relationship between migraine and mood disorders has been of long-standing interest to researchers and clinicians. Although a strong association has been demonstrated consistently for migraine and major depression, there has been less systematic research on the links between migraine and bipolar disorder.
Previous research has indicated that individuals afflicted with obsessive-compulsive disorder (OCD) have a very low rate of seeking help from mental health professionals. From standardized psychiatric interviews of 7,214 residents of Edmonton, Canada, we identified 172 subjects with a lifetime diagnosis of OCD; 63 (36.6%) had consulted a doctor about their symptoms.
View Article and Find Full Text PDFObjectives: To determine whether prevalent delirium is an independent predictor of mortality in older patients seen in emergency departments (EDs) and discharged home without admission.
Design: Prospective study with 18 months of follow-up.
Setting: EDs in two Montreal hospitals.
Objectives: To assess the association between selected physician characteristics and suboptimal duration of antidepressant use in the older outpatient population.
Design: Follow-up of patients who were prescribed an antidepressant treatment by a cohort of physicians in Quebec.
Setting: Community-based older outpatient population in Quebec.