Late post-natal neurometabolic development in healthy male rats using H and P magnetic resonance spectroscopy.

Brain metabolism evolves rapidly during early post-natal development in the rat. While changes in amino acids, energy metabolites, antioxidants or metabolites involved in phospholipid metabolism have been reported in the early stages, neurometabolic changes during the later post-natal period are less well characterized. Therefore, we aimed to assess the neurometabolic changes in male Wistar rats between post-natal days 29 and 77 (p29-p77) using longitudinal magnetic resonance spectroscopy (MRS) in vivo at 9.

Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C]glucose.

Hippocampus plays a critical role in linking brain energetics and behavior typically associated to stress exposure. In this study, we aimed to simultaneously assess excitatory and inhibitory neuronal metabolism in mouse hippocampus in vivo by applying FDG-PET and indirect C magnetic resonance spectroscopy (H-[C]-MRS) at 14.1 T upon infusion of uniformly C-labeled glucose ([U-C]Glc).

A double-quadrature radiofrequency coil design for proton-decoupled carbon-13 magnetic resonance spectroscopy in humans at 7T.

Purpose: Carbon-13 magnetic resonance spectroscopy ((13) C-MRS) is challenging because of the inherent low sensitivity of (13) C detection and the need for radiofrequency transmission at the (1) H frequency while receiving the (13) C signal, the latter requiring electrical decoupling of the (13) C and (1) H radiofrequency channels. In this study, we added traps to the (13) C coil to construct a quadrature-(13) C/quadrature-(1) H surface coil, with sufficient isolation between channels to allow simultaneous operation at both frequencies without compromise in coil performance.

Methods: Isolation between channels was evaluated on the bench by measuring all coupling parameters.