Publications by authors named "Guiliang Shi"
Article Synopsis
- * Cyclic tensile strain applied to P19 cells led to increased expression of key genes related to cardiomyocyte maturity and improved antioxidant capacity, indicating successful differentiation.
- * In animal tests, the matured P19 cells improved heart function and reduced damage markers in mice with myocardial infarction, highlighting their therapeutic potential.
Article Synopsis
- The study investigates the effectiveness of F-FDG PET imaging in predicting major adverse cardiac events (MACEs) in patients with suspected unstable angina (UA).
- It analyzed data from 265 patients, finding that F-FDG positivity is a strong independent predictor of MACEs.
- Results showed that incorporating F-FDG PET improved risk assessment compared to traditional clinical factors and scoring systems, enhancing the predictive C-index and other statistical measures of risk stratification.
Background: This study aimed to determine the clinical value of rest F-FDG imaging in Chinese patients with non-acute chest pain, normal ECG, negative troponin, and suspected UA.
Methods: 136 patients were prospectively included and underwent rest F-FDG PET imaging and coronary arteriography within 1 week.
Results: Obstructive CAD was diagnosed in 71 patients, and stenosis ≥ 70% was confirmed in 130 vascular territories.
Apixaban attenuates ischemia-induced myocardial fibrosis by inhibition of Gq/PKC signaling.
Biochem Biophys Res Commun
June 2018
It was previously found that patients with symptom of myocardial dysfunction had increased levels of thrombin. Apixaban is one of the novel oral anticoagulant drugs widely used in clinic. As the inhibitor of FXa (prothrombin), it inhibits prothrombin conversion into thrombin leading to thrombin deficiency in vivo.
View Article and Find Full Text PDFInterleukin-10 promotor -592A/C polymorphism is associated with slow coronary flow in Han Chinese.
Int J Clin Exp Pathol
September 2016
An accumulating body of evidence suggests that slow coronary flow (SCF) phenomenon seems to be an early-form of atherosclerosis and low-grade inflammation plays a major role in the atherosclerotic vascular processes. Interleukin (IL)-10 is a multifunctional cytokine involved in both innate and adaptive immune response. The aim of the present study is to investigate the association of IL-10 gene -592A/C polymorphism with SCF in Han Chinese.
View Article and Find Full Text PDF[Prognostic value of admission B-type natriuretic peptide on outcome for patients with congestive heart failure].
Zhonghua Xin Xue Guan Bing Za Zhi
June 2012
Objective: To observe the prognostic value of admission B-type natriuretic peptide (BNP) on outcome for patients with congestive heart failure (CHF).
Methods: Blood BNP levels, routine echocardiography and tissue Doppler image were obtained in 162 CHF patients [95 male, mean age: (71.8±3.
Article Synopsis
- * A study investigated the connection between interleukin 6 (IL-6) gene variations and thrombus presence in Han Chinese patients with AF, finding significant differences between those with and without thrombus.
- * The results showed that G allele carriers (CG + GG genotypes) have a significantly higher risk of developing thrombus or severe spontaneous echocontrast compared to those with the CC genotype, highlighting the G allele's role as an independent risk factor.
Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China).
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