Publications by authors named "Guili Zhang"

Article Synopsis
  • This study aimed to explore the link between plasma total homocysteine (tHcy) levels and behavioral and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies (DLB).
  • Among 82 DLB patients, a significant 92.7% exhibited clinically significant BPSD, with hallucinations and apathy being the most common symptoms; elevated tHcy levels were notably associated with higher NPI scores in DLB patients.
  • The findings suggest that controlling homocysteine levels might provide a new approach for managing BPSD in DLB, although further research with larger groups is needed to confirm these results.
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  • - The study highlights the alarming rise of plasmid-mediated tigecycline resistance in pathogens, notably in China, necessitating detailed research on their transmission mechanisms.
  • - Researchers collected and analyzed 775 samples from Guangdong between 2019 and 2020, identifying 146 resistant isolates, primarily from pigs, with two from humans, and revealing the bacteria’s multi-drug resistance profile.
  • - The findings indicate that high animal colonization rates contribute to human infections, emphasizing the importance of controlling this resistance spread due to its potential public health risks.
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Objective: To present the technical verification and clinical validation of the companion diagnostic assay, cobas® EZH2 Mutation Test (cobas EZH2 Test), targeting gain-of-function EZH2 mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). The focus is on patient clinical samples proving that the test met the performance criteria required for FDA approval of a companion diagnostic test.

Design: Epizyme, Inc.

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The continuous reduction of clinically available antibiotics has made it imperative to exploit more effective antimicrobial therapies, especially for difficult-to-treat Gram-negative pathogens. Herein, it is shown that the combination of an antimicrobial nanozyme with the clinically compatible basic amino acid L-arginine affords a potent treatment for infections with Gram-negative pathogens. In particular, the antimicrobial activity of the antimicrobial nanozyme is dramatically increased by ≈1000-fold after L-arginine stimulation.

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Background: The emergence and spread of hypervirulent carbapenem-resistant (hv-CRKP) is a potential epidemiological threat that needs to be monitored. However, the transmission and pathogenic characteristics of hv-CRKP in China remain unclear. We investigated the epidemiological characteristics of gut colonized hv-CRKP in a hospital in Guangdong Province, China.

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Background And Purpose: White matter hyperintensities (WMHs) are associated with cognitive deficits and worse clinical outcomes in dementia, but rare studies have been carried out of cognitive impairment in Lewy body disease (CI-LB) patients. The objective was to investigate the associations between WMHs and clinical manifestations in patients with CI-LB.

Methods: In this retrospective multicentre cohort study, 929 patients (486 with dementia with Lewy bodies [DLB], 262 with Parkinson's disease dementia [PDD], 74 with mild cognitive impairment [MCI] with Lewy bodies [MCI-LB] and 107 with Parkinson's disease with MCI [PD-MCI]) were analysed from 22 memory clinics between January 2018 and June 2022.

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Background: Blood brain barrier (BBB) breakdown is considered a potential mechanism of dementia. The Alzheimer's disease (AD) biomarkers and vascular factors are also associated with BBB permeability.

Objective: In the present study, the combination effects of neuropathological biomarkers of AD and chronic vascular risk factors for BBB were investigated.

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Background: Lewy body dementia is the second most common neurodegenerative dementia, but data concerning the onset age and clinical features in the prodromal stage remain limited in China.

Objective: To investigate the associations between onset age and clinical manifestations of cognitive impairment with Lewy bodies in a large-sample cohort.

Methods: We included 74 patients with mild cognitive impairment with Lewy bodies (MCI-LB), 533 patients with dementia with Lewy bodies (DLB), 118 patients with Parkinson's disease with MCI (PD-MCI), and 313 patients with Parkinson's disease dementia (PDD) in this multicenter cohort from 22 memory clinics of China from 1 January 2018 to 31 March 2022.

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Background: Research on sex ratios of Lewy body dementia is controversial, established in small samples, and rarely focused on prodromal stage. The objective is to investigate the clinical sex ratios (men/women) and their associations with clinical features among individuals with mild cognitive impairment with Lewy bodies (MCI-LB), dementia with Lewy bodies (DLB), Parkinson's disease with mild cognitive impairment (PD-MCI), and Parkinson's disease with dementia (PDD) in China.

Methods: We conducted a multicenter cohort study, including 1038 individuals with probable MCI-LB, DLB, PD-MCI, or PDD diagnosis from 22 memory clinics in China from January 2018 to March 2022, and recorded their demographic and clinical data by reviewing medical records.

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Article Synopsis
  • The study explores the connections between demographics, cognitive performance, APOE genotype, and MRI findings in patients with different types of mild cognitive impairment (MCI): amnestic (aMCI) and non-amnestic (naMCI).
  • It involved 130 aMCI patients, 58 naMCI patients, and 1,106 healthy controls, analyzing factors like serum folate, vitamin B12 levels, and white matter hyperintensities (WMH).
  • Results indicate that low serum folate and high plasma homocysteine levels are linked to both types of MCI, with APOE4 gene variant negatively impacting brain atrophy in aMCI, highlighting distinct underlying causes for the two M
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  • Clostridioides difficile poses a significant health threat in hospitals due to its ability to cause severe diarrhea, with a high carriage rate of 19.4% observed among patients in a study involving 894 fecal samples.
  • The genomic analysis revealed a diverse population structure with 36 distinct strains, where a notable 64.8% of isolates were toxigenic, and over half were multidrug-resistant.
  • The study highlights the role of asymptomatic carriers in the spread of C. difficile, suggesting the need for routine screening upon hospital admission to improve surveillance and prevention strategies.
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: Elevated plasma total homocysteine (tHcy) level, a known risk factor for vascular disease, is reported to be an independent risk factor for cognitive impairment and Alzheimer's disease (AD) in most studies. tHcy may also be associated with dementia with Lewy bodies (DLB). : To investigate the association between plasma tHcy levels and DLB or AD.

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  • China banned colistin in livestock feed due to rising colistin resistance gene mcr-1.
  • A time-series analysis was conducted on inpatient colonization data from 2011 to 2019.
  • The study aimed to uncover how the ban influenced the fluctuations of mcr-1 in hospitalized patients over time.
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Atherosclerosis has been effectively avoided with many therapies that lower low-density lipoprotein cholesterol. However, significant cardiovascular burden remains. The effect of raising high-density lipoprotein (HDL) has been confounded by other factors (such as lowering triglycerides or LDL) and unsuccessful when attempting to solely increase HDL.

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Background: Interleukin-37, which was discovered in 2000, is a natural suppressor of immune and inflammatory responses. Recent studies reported that IL-37 was abnormally expressed in several tumor patients, including those with hepatocellular carcinoma, gastric cancer, lung cancer, colon cancer, epithelial ovarian cancer, and multiple myeloma. However, the expression and potential function of IL-37 in leukemia remain unknown.

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  • A study was conducted to analyze the transmission dynamics of mcr-1 in Salmonella isolates across clinical, pig, and pork sources in Guangzhou, China, involving the collection of 598 clinical isolates, 936 pig faces, and 167 pork samples.
  • Eleven clinical Salmonella isolates were found to be mcr-1 positive, alongside positive samples from pig fecal matter and pork; all isolates demonstrated multi-drug resistance and carried mcr-1 genes on specific plasmids.
  • The findings suggest that the low prevalence of mcr-1-positive Salmonella is due to horizontal gene transfer rather than clonal transmission, highlighting the need for ongoing surveillance to monitor changes following colistin use restrictions in agriculture.
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Article Synopsis
  • The study focuses on the mobile colistin resistance gene (mcr-1), which poses a threat to polymyxin antibiotics, and highlights how banning colistin in livestock feed has reduced mcr-1 levels in animals, humans, and the environment.
  • Researchers discovered that some E. coli can carry mcr-1 on their chromosomes, indicating a stable, heritable form of resistance that could complicate efforts to manage antibiotic use.
  • The study systematically explores the genetic origins and transmission mechanisms of chromosomally-encoded mcr-1, revealing that it mainly arises from recombination events and a unique phage-like transmission pattern, emphasizing the need for vigilance against its potential resurgence.
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Rare chronic myelogenous leukemia (CML) patients manifested as the primary blast phase without a chronic and accelerated phase. The occurrence of a t(8;21) translocation in secondary blast phase of CML or Philadelphia chromosome positive acute myelogenous leukemia (Ph+ AML) has been reported previously. No case of primary blast phase of chronic myelogenous leukemia (CML-BP) bearing one clone with t(9;22) and t(8;21) simultaneously has been reported.

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Purpose: To assess the utility of the EGFR Mutation Test, with tissue and plasma, for first-line osimertinib therapy for patients with -mutated (m; Ex19del and/or L858R) advanced or metastatic non-small cell lung cancer (NSCLC) from the FLAURA study (NCT02296125).

Experimental Design: Tumor tissue m status was determined at screening using the central cobas tissue test or a local tissue test. Baseline circulating tumor (ct)DNA m status was retrospectively determined with the central cobas plasma test.

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BACKGROUND The aim of this study was to evaluate 2 methods to treat patients with thoracic lumbar spine fracture with merging spinal cord injury, including complications of surgery and the influence of inflammatory factors. MATERIAL AND METHODS Eighty patients were randomly divided into an anterior decompression group (study group) or a posterior decompression group (control group) to observe perioperative complications, evaluate preoperative and postoperative nerve function, and evaluate the 6-month injured vertebral height and Cobb angle of the vertebral bodies. The expression level of TGF-β₂ on day 1, day 7, day 15, and day 30 after treatment was detected by enzyme-linked immunosorbent assay (ELISA).

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Interleukin-35 (IL-35) is a newly discovered anti-inflammatory cytokine predominantly released by regulatory T cells (Tregs) and may serve an important role in the pathogenesis of autoimmune diseases. The levels of IL-35 and corresponding Treg frequencies in patients with rheumatoid arthritis (RA) have scarcely been reported. The present study aimed to detect serum IL-35 levels and Treg frequencies in patients with RA, and analyze their association with each other and with indicators of RA.

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Objective: Patients with advanced non-small-cell lung cancer (NSCLC) with an adenocarcinoma component are recommended to undergo epidermal growth factor receptor (EGFR) mutation testing when being considered for EGFR targeted therapy. We conducted an exploratory analysis to inform the clinical utility of EGFR mutation testing in blood cell-free DNA using the cobasEGFR Mutation Test v2.

Materials And Methods: Two EGFR mutation tests, a tissue-based assay (cobas v1) and a tissue- and blood-based assay (cobas v2) were used to analyze matched biopsy and blood samples (897 paired samples) from three Asian studies of first-line erlotinib with similar intent-to-treat populations.

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Laboratory testing for thrombophilia is complicated but essential for diagnosis. In 2017, the cobas® Factor II and Factor V Test (cobas F2F5 test) was launched for use with the cobas z 480 analyzer. This qualitative polymerase chain reaction test enables multiplex Factor II and Factor V testing with flexible reporting and workflow efficiency.

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cMaf is a leucine-zipper transcription factor that is involved in cell differentiation, oncogenic transformation, and human diseases; however, the functions of cMaf in inflammatory responses in macrophages are still not fully understood. Western blot analysis showed that cMaf expression was induced by lipopolysaccharide (LPS) stimulation in mouse macrophages. An enzyme-linked immunosorbent assay was performed to detect the level of expression of inflammatory cytokines after knockdown of cMaf expression in macrophages using a small interfering RNA (siRNA).

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