Iron-Rich Semiconducting Polymer Dots for the Combination of Ferroptosis-Starvation and Phototherapeutic Cancer Therapy.

Chemodynamic therapy (CDT) has emerged as an outstanding antitumor therapeutic method due to its selectivity and utilization of tumor microenvironment. However, there are still unmet requirements to achieve a high antitumor efficiency, including the tumor accumulation of catalyst and enrichment of reactants of Fenton reaction. Here, an iron-loaded semiconducting polymer dot modified with glucose oxidase (Pdot@Fe@GOx) is reported to deliver iron ions into tumor tissues and in situ generation of hydrogen peroxide in tumors.

Biocompatibility and Biological Effects of Surface-Modified Conjugated Polymer Nanoparticles.

Semiconductiong polymer nanoparticles (Pdots) have a wide range of applications in biomedical fields including biomolecular probes, tumor imaging, and therapy. However, there are few systematic studies on the biological effects and biocompatibility of Pdots in vitro and in vivo. The physicochemical properties of Pdots, such as surface modification, are very important in biomedical applications.

Green Synthesis of Nitrogen-Doped Carbon Dots from Fresh Tea Leaves for Selective Fe Ions Detection and Cellular Imaging.

In this research, we successfully developed a green, economical and effective one-step hydrothermal method for the synthesis of fluorescent nitrogen-doped carbon dots (N-CDs) by utilizing fresh tea leaves and urea as the carbon and nitrogen sources, respectively. The obtained N-CDs were characterized by TEM, XPS and FT-IR. We found that the N-CDs were near-spherical with an average size of about 2.

Carbon dots: synthesis, properties and biomedical applications.

Carbon dots (CDs) are a new type of carbon nanomaterial that have unique physical and chemical properties, good biocompatibility, low toxicity, and easy surface functionalization, making them widely used in biological imaging, environmental monitoring, chemical analysis, targeted drug delivery, disease diagnosis, therapy, etc. In this review, our content is mainly divided into four parts. In the first part, we focused on the preparation methods of CDs, including arc discharge, laser ablation, electrochemical oxidation, chemical oxidation, combustion, hydrothermal/solvent thermal, microwave, template, method etc.