Disc degeneration affects the intervertebral discs, potentially leading to conditions like herniation and stenosis, with genetic factors playing a larger role than environmental ones.
A narrative review of recent literature identifies several genes linked to disc degeneration, including those related to collagen and other proteins.
The review highlights advancements in understanding the genetic mechanisms behind disc degeneration, focusing on gene associations, single-nucleotide polymorphisms, and genetic-environmental interactions.