677C>T (rsRS1801133) variant is associated with hyperhomocysteinemia but not with clinical severity in patients with peripheral arterial disease.

Background: The 677C>T variant's involvement with hyperhomocysteinemia and peripheral arterial disease (PAD) is still unclear.

Objectives: To evaluate associations between the 677C>T (rs1801133) variant and susceptibility to and severity of PAD and homocysteine (Hcy) levels.

Methods: The study enrolled 157 PAD patients and 113 unrelated controls.