Peptide L13S Derived from the BRN2 POU Domain Reduces Metastasis and Inhibits Cell Migration and Invasion .

Background/aim: The Brain-Specific Homeobox/POU Domain Protein 2 (BRN2) transcription factor supports melanoma progression by regulating the expression of several genes involved in cell migration and invasion. We hypothesized that a peptide designed based on the POU domain of BRN2 could block the BRN2 transcription activity and, consequently, reduce metastasis.

Materials And Methods: Cell viability was accessed by Trypan Blue exclusion dye assay and xCelligence platform.