Publications by authors named "Guilherme Cardoso Bernardino"
Invert Neurosci
June 2011
Article Synopsis
- Studies indicate that neuronal loss in Parkinson's disease may be linked to calcium channel activity in the brain, particularly due to aging and increased intracellular calcium levels.
- Other contributing factors to dopaminergic cell death include the overproduction of reactive oxygen species, suggesting a potential therapeutic role for calcium channel blockers and antioxidants like dihydropyridines and resveratrol.
- In an experiment with Drosophila melanogaster, none of the tested drugs, including isradipine, nifedipine, and resveratrol, were effective in preventing locomotor deficits caused by paraquat, and some even caused motor deficits on their own.
