Computational simulation on the study of Tacrolimus and its improved dermal retention using Poly(Ԑ-caprolactone) nanocapsules.

Tacrolimus (TAC) is a drug from natural origin that can be used for topical application to control autoimmune skin diseases such as atopic dermatitis, psoriasis, and vitiligo. Computational simulation based on quantum mechanics theory by solving Schrödinger Equation for n-body problem may allow the theoretical calculation of drug geometry, charge distribution and dipole moment, electronic levels and molecular orbitals, electronic transitions, and vibrational transitions. Additionally, the development of novel nanotechnology-based delivery systems containing TAC can be an approach for reducing the dose applied topically, increasing dermal retention, and reducing the reported side effects due to the controlled release pattern.

Cancer care in the COVID-19 era and psychosocial impacts on oncology nursing in Brazil.

Introduction: Globally, Brazil has the third highest number of confirmed COVID-19 cases and the second highest number of deaths related to COVID-19 at the time of writing. Maintaining cancer care has been a challenge for patient safety and for the physical and mental health of oncology nurses.

Objectives: To describe which effects of the COVID-19 pandemic on cancer care could already be evaluated and to identify the psychosocial impact on cancer nurses in Brazil.

Characterization and In Vitro and In Vivo Evaluation of Tacrolimus-Loaded Poly(ε-Caprolactone) Nanocapsules for the Management of Atopic Dermatitis.

Background: Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application of the drug often causes adverse side effects in some patients. Hence, drug nanoencapsulation could be used as an improved novel therapy to mitigate the adverse effects and enhance bioavailability of the drug.

Validation of Analytical Methods for Tacrolimus Determination in Poly(-caprolactone) Nanocapsules and Identification of Drug Degradation Products.

The aim of this paper was to use chromatographic tools for validating an analytical method for the tacrolimus (TAC) determination in polymeric nanocapsules and for identifying the drug degradation products after alkaline stress. A rapid Ultra-High-Performance Liquid Chromatography coupled with photo-diode array (UHPLC-PDA) method was successfully performed using the following chromatographic conditions: the Shimadzu Shim-pack XR-ODS III C18 column (100 mm×2.00 mm, 2.

Psychological exhaustion of nursing professionals who care for patients with neoplasms.

Objective: Identify, analyze and understand the social representations of nursing professionals about burnout syndrome.

Method: Qualitative study with nursing professionals who worked in the direct assistance to oncologic patients, conducted through semi-structured interview, using the technique of content analysis, anchoring the interpretations in the theory of social representations.

Results: Seven professionals participated; after analysis, two categories emerged: "The stress of professionals, the naturalization of suffering and self-care strategies"; and "Ressignifications, learning in the oncologic sector and network gaps".

Active semi-supervised learning for biological data classification.

Due to datasets have continuously grown, efforts have been performed in the attempt to solve the problem related to the large amount of unlabeled data in disproportion to the scarcity of labeled data. Another important issue is related to the trade-off between the difficulty in obtaining annotations provided by a specialist and the need for a significant amount of annotated data to obtain a robust classifier. In this context, active learning techniques jointly with semi-supervised learning are interesting.

Exploring Active Learning Based on Representativeness and Uncertainty for Biomedical Data Classification.

Nowadays, there is an abundance of biomedical data, such as images and genetic sequences, among others. However, there is a lack of annotation to such volume of data, due to the high costs involved to perform this task. Thus, it is mandatory to develop techniques to ease the burden of human annotation.

Fatty acid profile in vertical strata of elephant grass subjected to intermittent stocking.

The milk and meat from animals with a pasture-based diet have higher proportions of CLA and C18:3 and lower omega-6:omega-3 ratios than products from animals with diets based on corn silage and concentrate. However, most of the published studies have evaluated fatty acid profiles in temperate climate grasses and the literature with tropical grasses is scarce. Thus, the aim of this study was to evaluate the morphological and fatty acid compositions in the vertical strata of elephant grass (Pennisetum purpureum Schum.