Combining lung-protective strategies in experimental acute lung injury: The impact of high-frequency partial liquid ventilation.

Objective: To evaluate the independent and combined effects of high-frequency oscillatory ventilation (HFOV) and partial liquid ventilation (PLV) on gas exchange, pulmonary histopathology, inflammation, and oxidative tissue damage in an animal model of acute lung injury.

Design: Prospective, randomized animal study.

Setting: Research laboratory of a health sciences university.

[The impact of mechanical ventilation strategies that minimize atelectrauma in an experimental model of acute lung injury].

Objective: To evaluate whether ventilation strategies that target alveolar stabilization and prevention of atelectrauma would be associated with more favorable physiologic outcomes in a combined model of acute lung injury.

Methods: Thirty-nine rabbits were instrumented and ventilated with FiO(2) of 1.0.