CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN.

Background: CR6-interacting factor 1 (CRIF1), a multifunctional protein that affects mitochondrial function and cell senescence, plays a regulatory role in heart-related diseases. However, whether CRIF1 participates in myocardial senescence by regulating mitochondrial function remains unclear.

Methods: Doxorubicin (DOX)-induced C57BL/6 mice to construct mouse myocardial senescence model, and the myocardial function indicators including lactate dehydrogenase (LDH) and Creatine kinase isoform MB (CK-MB) were assessed.

[A study of the relationship between remodeling of left ventricle and endothelial injury and pro-inflammatory mediators in different stages of essential hypertension].

Objective: To explore the relationship between left ventricular remodeling and vascular endothelial injury and pro-inflammatory mediators in different stages of essential hypertension.

Methods: Patients were grouped in according to the duration of the disease. The control group consisted of patients with history of hypertension for 6 months to 1 year (35 cases), patients with a history of 3 years were categorized as group A (38 cases), patients with 5-year history as group B (32 cases), 8-year history as group C (33 cases), 13-year history as group D (34 cases), 15-year history as group E (32 cases).