Renal Involvement of Immunoglobulin G4-Related Disease Presenting as a Solitary Hypermetabolic Mass Mimicking Renal Tumor on 18 F-FDG PET/CT.

A 62-year-old woman with a 5-year history of diabetes insipidus was found with a solitary renal mass in contrast-enhanced CT. 18 F-FDG PET/CT showed a hypermetabolic mass in the right kidney. Besides, there was increased uptake in the pituitary stalk.

Dynamic PET/CT scan of Ga-FAPI-04 for the optimal acquisition time in suspected malignant hepatic cancer patients.

Purpose: Dynamic PET/CT scan of Ga-FAPI-04 in patients with suspected malignant hepatic lesions were retrospectively analyzed to find the optimal acquisition time with better lesion detection rate.

Methods: Twenty-two patients with lesions confirmed by CT or MRI were performed with dynamic Ga-FAPI-04 PET/CT scan. Tracer uptake of lesions and normal organs at different time points were analyzed.

Development and comparison of three Zr-labeled anti-CLDN18.2 antibodies to noninvasively evaluate CLDN18.2 expression in gastric cancer: a preclinical study.

Background: Isoform 2 of claudin 18 (CLDN18.2) is overexpressed in gastric cancer and may be a promising imaging target. In this study, we constructed three anti-CLDN18.

Increased Activity Due to Fractures Does Not Significantly Affect the Accuracy of 68Ga-DOTATATE PET/CT in the Detection of Culprit Tumor in the Evaluation of Tumor-Induced Osteomalacia.

Objective: Ga-DOTATATE PET/CT is currently the most common imaging modality in localizing culprit tumors, which can result in tumor-induced osteomalacia (TIO). Fracture, which is one of the most common consequences of the TIO, can also lead to increased Ga-DOTATATE activity and potentially affect the accuracy of Ga-DOTATATE PET/CT imaging. The aim of this investigation is to evaluate whether the increased Ga-DOTATATE activity at the sites of the fracture will cause interpretation difficulty in the localizing the culprit tumor causing TIO.

miR-125b is downregulated in systemic lupus erythematosus patients and inhibits autophagy by targeting UVRAG.

Systemic lupus erythematosus (SLE) is a severe autoimmune disease and the pathogenesis remains incompletely understood. This study aimed to investigate the role of miR-125b in the pathogenesis of SLE and explore the underlying mechanism. Compared to healthy controls, the expression of miR-125b decreased in peripheral blood mononuclear cells (PBMCs) of SLE patients.

Comparison among Reconstruction Algorithms for Quantitative Analysis of C-Acetate Cardiac PET Imaging.

Objective: Kinetic modeling of dynamic C-acetate PET imaging provides quantitative information for myocardium assessment. The quality and quantitation of PET images are known to be dependent on PET reconstruction methods. This study aims to investigate the impacts of reconstruction algorithms on the quantitative analysis of dynamic C-acetate cardiac PET imaging.

Preclinical PET imaging of HIP/PAP using 1'-F-fluoroethyl--D-lactose.

Purpose: This study aims at preclinical evaluation of a recently reported lactose analogue, 1'-F-fluoroethyl--D-lactose (F-FEL), in binding to hepatocarcinoma-intestine-pancreas and pancreatitis-associated protein (HIP/PAP) and .

Methods: In this study, a multifunctional module was employed for the automated synthesis of F-FEL. Additional radiochemical purity, biodistribution, and competition, metabolic stability and micro-PET studies were performed using T3M4 and SK-BR-3 xenografts.

Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement: Two case reports and literature review.

Rationale: Pancreatic acinar cell carcinoma (ACC) is a rare malignant tumor of exocrine pancreas. It is typically a well-marginated large solid mass arising in a certain aspect of the pancreas. Diffuse involvement of ACC in the pancreas is very rare, and may simulate pancreatitis in radiological findings.

Solitary Plasmacytoma in the Renal Pelvis on 18F-FDG and 11C-Acetate PET/CT.

A 70-year-old man was incidentally found to have an occupying lesion in the left renal pelvis by ultrasonography during a routine health examination. CT images suggested renal cell carcinoma. FDG PET/CT scan was acquired for staging.