Catalytic Enantioselective Nucleophilic Addition to Arynes by a New Quaternary Guanidinium Salt-Based Phase-Transfer Catalyst.

Owing to the mild generation methods, arynes have been widely used in synthetic chemistry. However, achieving asymmetric organocatalytic reactions with arynes remains a formidable and infrequent challenge, primarily because these neutral and transient species tend to spontaneously quench. To address this issue, a solid-liquid phase-transfer strategy is devised in which the generation speed of arynes could be controlled by the generated fluoride-based chiral phase-transfer catalyst.

Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China.

Objectives: To classify subgroups of cancer-related symptoms in patients with multiple myeloma (MM) during treatment and examine between-group differences in demographic and clinical characteristics in addition to functional status.

Design: Cross-sectional survey study.

Setting: Haematology department of two tertiary hospitals affiliated with Guilin Medical University in China.

Microbial network signatures of early colonizers in infants with eczema.

In this longitudinal cohort study, our results demonstrated that there are rhythmic changes in gut microbial network signatures in early life, and healthy infants adopt more complex and stable network structure in their gut microbiota than that of the infants with eczema.

Probiotic Consortia and Their Metabolites Ameliorate the Symptoms of Inflammatory Bowel Diseases in a Colitis Mouse Model.

Inflammatory bowel disease (IBD) has become a global public health problem. Although the pathogenesis of the disease is unknown, a potential association between the gut microbiota and inflammatory signatures has been established. Probiotics, especially or , are orally taken as food supplements or microbial drugs by patients with IBD or gastrointestinal disorders due to their safety, efficacy, and power to restore the gut microenvironment.

Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis.

Background: Satellite cells (SCs) are critical to skeletal muscle regeneration. Inactivation of SCs is linked to skeletal muscle loss. Transferrin receptor 1 (Tfr1) is associated with muscular dysfunction as muscle-specific deletion of Tfr1 results in growth retardation, metabolic disorder, and lethality, shedding light on the importance of Tfr1 in muscle physiology.

Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes.

Iron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic properties of adipocytes is currently unknown. Using integrative analyses of multi-omics data, transferrin receptor 1 (Tfr1) is identified as a candidate for regulating thermogenesis in beige adipocytes.

Kuijieling, a Chinese medicine alleviates DSS-induced colitis in C57BL/6Jmouse by improving the diversity and function of gut microbiota.

Ulcerative colitis (UC) is a gastrointestinal disease. The link between gut microbiota and the inflammatory response in the gut has been recently established. Restoration of gut microbiota suppresses inflammatory signaling.

miR-145-5p Regulates the Proliferation, Migration and Invasion in Cervical Carcinoma by Targeting KLF5.

Objective: Cervical carcinoma (CC) is a serious threat to women's health and few effective therapeutic methods have been discovered. The purpose of this study is to explore the underlying mechanism of miR-145-5p in CC.

Methods: Bioinformatics methods were employed to analyze the gene expression data of CC from TCGA database.

Catalytic Asymmetric Ring-Opening/Cyclopropanation of Cyclic Sulfur Ylides: Construction of Sulfur-Containing Spirocyclopropyloxindoles with Three Vicinal Stereocenters.

A highly efficient asymmetric ring-opening/cyclopropanation reaction of ( E)-3-(oxyethylidene)-2-oxoindolines with 1-alkyl-3-oxotetrahydro-1 H-thiophen-1-ium salts as cyclic sulfur ylides was realized by using a chiral N, N'-dioxide/Mg(OTf) complex as catalyst. A range of sulfur-containing syn, anti spirocyclopropyloxindoles with three contiguous stereocenters were obtained in excellent yields with excellent dr and good ee values under mild reaction conditions. The origin of stereoselectivity was discussed.

The Application of Cognitive Remediation Therapy in The Treatment of Mental Disorders.

Cognitive impairment is common in patients with mental disorders. At present, one of the only effective ways to improve cognitive impairment is cognitive remediation therapy. This article reviews the application of cognitive remediation therapy in the treatment of mental disorders.

Long-term follow-up of mri-guided bilateral anterior capsulotomy in patients with refractory schizophrenia.

Aim: To determine whether there is a long-term benefit of MRI-guided bilateral anterior capsulotomy in the treatment of refractory schizophrenia.

Methods: 116 patients (16 patients did not complete the follow-up evaluation) with refractory schizophrenia who underwent capsulotomy were included. The treatment effect was evaluated using a series of international rating scales.

Deep-brain stimulation for anorexia nervosa.

Objective: Anorexia nervosa (AN) is a complex and severe, sometimes life-threatening, psychiatric disorder with high relapse rates under standard treatment. After decades of brain-lesioning procedures offered as a last resort, deep-brain stimulation (DBS) has come under investigation in the last few years as a treatment option for severe and refractory AN.

Methods And Results: In this jointly written article, Sun et al.

Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action.

Despite recent advances in understanding the pathophysiology of schizophrenia and the mechanisms of antipsychotic drug action, the development of biomarkers for diagnosis and therapeutic monitoring in schizophrenia remains challenging. Metabolomics provides a powerful approach to discover diagnostic and therapeutic biomarkers by analyzing global changes in an individual's metabolic profile in response to pathophysiological stimuli or drug intervention. In this study, we performed gas chromatography-mass spectrometry based metabolomic profiling in serum of unmedicated schizophrenic patients before and after an 8-week risperidone monotherapy, to detect potential biomarkers associated with schizophrenia and risperidone treatment.