Synthesis of reusable hierarchical Pore PVDF-MIL-101(Cr) foam for Solid phase extraction of fluoroquinolones from water and its adsorption behavior for anionic and cationic dyes.

In this study, a novel hierarchical pore MIL-101(Cr) foam (HPF-MIL-101) was designed and prepared using the sacrificial template method with NaCl as the sacrificial template. This method involved grinding, heating, and washing the NaCl template to produce HPF-MIL-101, with PVDF as the binder and MIL-101(Cr) as the adsorbent. This preparation process is both straightforward and cost-effective, avoiding the use or generation of any organic reagents, thereby offering an environmentally sustainable approach for producing metal-organic framework (MOF) composites.

Preparation of cylindrical Chitosan/β-Cyclodextrin/MIL-68(Al) foam column for solid-phase extraction of sulfonamides in water, urine, and milk.

This study describes the preparation of a cylindrical polymer foam column termed Chitosan/β-Cyclodextrin/MIL-68(Al) (CS/β-CD/MIL-68(Al)). An ice template-freeze drying technique was employed to prepare the CS/β-CD/MIL-68(Al) foam column by embedding MIL-68(Al) in a polymer matrix comprising cross-linked chitosan (CS) and β-cyclodextrin (β-CD). The cylindrical CS/β-CD/MIL-68(Al) foam was subsequently inserted into a syringe to develop a solid phase extraction (SPE) device.

Protein Tyrosine Phosphatase 1B Inhibitors of Based on the Spectrum-Effect Relationship by Q-Marker Selection.

(), a traditional anti-diabetic medicine mainly composed of flavonoids and isoflavones, has a long history in diabetes treatment in China. However, the anti-diabetic active component is still unclear. Recently, protein tyrosine phosphatase 1B (PTP1B) has been a hot therapeutic target by negatively regulating insulin signaling pathways.

Preparation of COPs Mixed Matrix Membrane for Sensitive Determination of Six Sulfonamides in Human Urine.

In this study, TpDMB-COPs, a specific class of covalent organic polymers (COPs), was synthesized using Schiff-base chemistry and incorporated into a polyvinylidene fluoride (PVDF) polymer for the first time to prepare COPs mixed matrix membranes (TpDMB-COPs-MMM). A membrane solid-phase extraction (ME) method based on the TpDMB-COPs-MMM was developed to extract trace levels of six sulfonamides from human urine identified by high-performance liquid chromatography (HPLC). The key factors affecting the extraction efficiency were investigated.

Preparation of a Multifunctional and Multipurpose Chitosan/Cyclodextrin/MIL-68(Al) Foam Column and Examining Its Adsorption Properties for Anionic and Cationic Dyes and Sulfonamides.

A multifunctional cylindrical hybrid foam column, referred to as the chitosan/cyclodextrin/MIL-68(Al) (CS/CD/MIL-68(Al)) foam column, was prepared for the first time. The prepared foam column could be used for the adsorption/removal of hydrophilic and hydrophobic contaminants by different forms. Here, it was placed in hydrophilic dye solutions to investigate the adsorption behavior of methylene blue and trypan blue.

A membrane solid-phase extraction method based on MIL-53-mixed-matrix membrane for the determination of estrogens and parabens: Polyvinylidene difluoride membrane versus polystyrene-block-polybutadiene membrane.

In this work, MIL-53(Al), as an inorganic "filler" component, was embedded in polyvinylidene difluoride (PVDF) and polystyrene-block-polybutadiene (SBS) matrices to prepare two mixed-matrix membranes (MMMs), using a simpler method than that previously reported. The PVDF and SBS membranes retained much of the properties of PVDF, SBS, and native MIL-53(Al). The prepared MMMs were then placed in a vortex-stirred sample solution to develop a membrane solid-phase extraction method to extract estrogens and parabens, which were determined by high-performance liquid chromatography with fluorescence detection.

Preparation and chiral resolution properties of bridged bis(cyclodextrin)s hybrid spheres for high performance liquid chromatography.

Selenium-bridged bis(β-cyclodextrin)s organic-inorganic hybrid silica material with regular spherical shape as new type of chiral stationary phase was directly synthesized under the one-pot hydrothermal synthesis method, and the chiral stationary phase was further characterized by infrared spectroscopy, scanning electron microscopy, thermogravimetry, and elemental analysis. The results of chiral separation showed that eight chiral compounds including various types of chiral alcohols and flavanone were successfully separated in the reversed-phase separation mode by high performance liquid chromatography, which showed the better chiral resolution effect than that on the C2 position of single β-cyclodextrin. The mechanism of chiral separation was likely due to multiple interactions such as inclusion, hydrogen bonding, electrostatic interaction, dipole-dipole interaction, and the synergistic effect of two cyclodextrins during the chiral resolution process.

Cancer-associated fibroblasts in gastric cancer affect malignant progression via the CXCL12-CXCR4 axis.

Cancer-associated fibroblasts (CAFs) are principal constituents of the tumor microenvironment (TME) and play a critical role in tumor progression. The CXCL12/CXCR4 axis regulates multiple facets of the TME. The aim of this study was to determine the relationship between CXCL12 expression in CAFs and the malignant progression of gastric cancer (GC).

Magnetic Resonance Diffusion Kurtosis Imaging versus Diffusion-Weighted Imaging in Evaluating the Pathological Grade of Hepatocellular Carcinoma.

Purpose: To investigate the diagnostic efficacy of diffusion kurtosis imaging (DKI) and conventional diffusion-weighted imaging (DWI) for pathological grading.

Methods: From December 2015 to January 2017, consecutive patients suspected of having hepatocellular carcinoma (HCC) without prior treatment were prospectively enrolled in this study. MRI examinations were performed before surgical treatment.

Detection of Dysplastic Liver Nodules in Patients with Cirrhosis Using the Multi-Arterial CAIPIRINHA-Dixon-TWIST-Volume-Interpolated Breath-Hold Examination (MA-CDT-VIBE) Technique in Dynamic Contrast-Enhanced Magnetic Resonance Imaging.

BACKGROUND The multi-arterial CAIPIRINHA-Dixon-TWIST-volume-interpolated breath-hold examination (MA-CDT-VIBE) sequence has the advantage of detecting hypervascular lesions during the arterial phase of magnetic resonance imaging (MRI) of the liver. Liver cirrhosis may be associated with dysplastic nodules. This study aimed to compare the use of routine liver MRI sequences with the MA-CDT-VIBE sequence to identify dysplastic liver nodules in patients with liver cirrhosis.

Development and application of vortex-assisted membrane extraction based on metal-organic framework mixed-matrix membrane for the analysis of estrogens in human urine.

A vortex-assisted membrane extraction (VA-ME) method based on several metal-organic framework mixed-matrix membranes (MOF-MMMs) was firstly developed and applied for the analysis of four estrogens in human urine. The MOF-MMMs, with high MOF loading (∼67 wt%), were prepared using a facile approach by embedding the MOFs in a polyvinylidene difluoride matrix. The method was suitable for a wide variety of MOF materials, and the incorporated MOFs retained their unique properties.

A combination of computational-experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS.

In this work, computational and experimental methods were used to study the adsorption of estrogens and glucocorticoids on metal-organic frameworks (MOFs). Computer-aided molecular simulation was applied to predict the adsorption of eight analytes on four MOFs (MIL-101(Cr), MIL-100(Fe), MIL-53(Al), and UiO-66(Zr)) by examining molecular interactions and calculating free binding energies. Subsequently, the four water-stable MOFs were synthesized and evaluated as adsorbents for the target hormones in aqueous solution.

Drug-protein binding mechanism of juglone for early pharmacokinetic profiling: Insights from ultrafiltration, multi-spectroscopic and molecular docking methods.

Juglone (JL), as one of the major bioactive components present in the bark of Juglans mandshruica Maxim, exhibits versatile bioactivities, especially anti-cancer activity. To better understand the pharmacokinetic properties of juglone, the protein binding rate of juglone was determined by ultrafiltration method, and the binding affinity and mechanism between JL and human serum albumin (HSA) was investigated in vitro through multi-spectroscopic, thermodynamic, and molecular modeling methods. The binding degree of JL was measured more than 99.

[Optimum extraction technology of total triterpenoids from Hypodematium sinense].

Objective: To optimize the extraction technology of total triterpenoids from Hypodematium sinense.

Methods: With 5% vanillin-glacial acetic acid solution and 72% sulfuric acid as chromogenic agent and the content of total tripenoids as index,using single factor experiment and orthogonal test,the optimal extraction condition was determined.

Results: The optimal conditions were solid-liquid ratio 1:12, 60% ethanol concentration, and ultrasonic extraction time of 60 min at 60 degrees C.

Adsorption behavior of EDTA-graphene oxide for Pb (II) removal.

Chelating groups are successfully linked to graphene oxide (GO) surfaces through a silanization reaction between N-(trimethoxysilylpropyl) ethylenediamine triacetic acid (EDTA-silane) and hydroxyl groups on GO surface. EDTA-GO was found to be an ideal adsorbent for Pb(II) removal with a higher adsorption capacity. EDTA-modification enhances the adsorption capacity of GO because of the chelating ability of ethylene diamine triacetic acid.

[Polymorphism of CYP11A1 gene in Chinese patients with polycystic ovarian syndrome].

Objective: To investigate the association between polymorphism of cytochrome P450 subfamily XIA polypeptide 1 (CYP11A1) gene and polycystic ovarian syndrome (PCOS) in Chinese population.

Methods: From May 2005 to Dec. 2008, 290 PCOS cases treated in the First affiliated hospital of Anhui Medical University matched with 344 reproductive women as controls were enrolled in this study.

No association of the insulin gene VNTR polymorphism with polycystic ovary syndrome in a Han Chinese population.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with an increased risk of type II diabetes mellitus. The results of previous research about the association of the VNTR polymorphism in 5-prime flanking region of the insulin (INS) gene with PCOS have been inconsistent. The present study was to investigate the association of the INS-VNTR polymorphism with PCOS in a Han Chinese population.

Qualitative and quantitative analysis of flavonoids in the leaves of Isatis indigatica Fort. by ultra-performance liquid chromatography with PDA and electrospray ionization tandem mass spectrometry detection.

A novel method based on ultra-performance liquid chromatography with photo diode array and electrospray ionization tandem mass spectrometry detection (UPLC-PDA-ESI-MS/MS) was developed for the qualitative and quantitative analysis of flavonoids in the leaves of Isatis indigotica Fort. (Daqingye). The separation was carried out on an Acquity UPLC BEH C(18) column with 0.

[The current prevalence of intestinal parasites in Beijing].

Following the requirements of the "National survey on the current status of the major human parasitic diseases", the investigation was conducted in June-October 2002 in 5 districts (counties) of Beijing with a sample of 7912 people. The overall prevalence rate of intestinal parasites was 2.9%, significantly lower than the result from the first survey in 1988-1989 (34.

[Evaluation on the safety and immunogenicity of Canada split influenza virus vaccine].

Objective: To evaluate the safety and immunogenicity of Canada split influenza virus vaccine.

Methods: Cluster samples were by randomly chosen and divided into split vaccination group and homoimported influenza vaccination group.

Results: After injection, fever-reaction and local reaction rates of 'trial' group were found as 3.

[Study on the risk factors related to severe acute respiratory syndrome among close contactors in Beijing].

Objective: To understand the risk factors on severe acute respiratory syndrome (SARS) among their contacts and to develop effective strategy for its control.

Methods: Available epidemiological data of SARS cases and close contacts were reviewed and analyzed by SPSS.

Results: Out of the 2195 close contacts, 138 (6.