Publications by authors named "Guihua Fan"
Detection of anti-calreticulin antibody in the sera of Chinese patients with primary Sjögren syndrome.
Semin Arthritis Rheum
October 2024
Article Synopsis
- Primary Sjögren syndrome (pSjS) is a common autoimmune disease marked by overstimulation of B cells and high levels of autoantibodies, prompting research into autoantibodies related to salivary gland epithelial cells (SGECs) for potential biomarkers and understanding disease mechanisms.
- The study used various methods, including immunofluorescence and mass spectrometry, to identify autoantibodies against SGECs in pSjS patients, comparing the results with healthy individuals.
- The anti-calreticulin (CALR) antibody was identified as a significant marker in pSjS, found in 30.83% of patients and linked to clinical symptoms like weight loss and vasculitis, along
Article Synopsis
- - The study aimed to analyze how COVID-19 affects patients with Takayasu's arteritis (TAK), particularly focusing on infection rates and symptoms among this population compared to their co-residents in China.
- - Results showed that TAK patients had a lower infection rate (79.13% vs 90.67%) but experienced more gastrointestinal issues, sleep problems, and multi-organ symptoms post-infection, with a notable percentage suffering from post-acute sequelae of COVID-19 (PASC).
- - Despite experiencing more symptoms, TAK patients did not have severe outcomes from COVID-19, and infection did not significantly increase the risk of disease relapse; however, those on csDMARDs treatment might be more susceptible
Background/objective: The neurological involvement associated with primary Sjögren's syndrome (pSS) can be life threatening. However, the specific characteristics of pSS-related neurological involvement remain obscure. This study aimed at determining the clinical characteristics of this neurological involvement in patients with pSS.
View Article and Find Full Text PDFPrimary Sjögren's syndrome (pSS) is a rheumatic disease characterized by the destruction of salivary and lacrimal glands, and its pathogenesis mechanism remains unclear. Gq is the -subunit of the heterotrimeric Gq protein. Researches demonstrated that Gq was involved in the pathogenesis regulation of several rheumatic diseases.
View Article and Find Full Text PDFObjective: To explore and develop three-dimension (3D) virtual reality (VR) liver model and convert computed tomography data into a fully 3D VR environment for display, measure and manipulation.
Methods: 3D-reconstruction of liver was restored from spiral computed tomography (CT) data by using LiVirtue software. Dextrobeam was used to view the 3D model in the VR environment.