Telbivudine Treatment during Late Pregnancy Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Retrospective Study.

Purpose: To investigate the efficacy of telbivudine (LdT) in blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) during late pregnancy.

Methods: A total of 651 pregnant women aged 18-40 in Nantong Third People's Hospital and Hospital affiliated to Nantong University with positive hepatitis B surface antigen (HBsAg) and HBV DNA were enrolled between January 2011 and December 2015. Patients with HBV DNA≥10 copies/mL (n=251) received LdT during late pregnancy according to the patients' will, while 136 high viral patients with HBV DNA≥10 copies/mL who did not take LdT therapy and 268 low viral patients with HBV DNA<10 copies/mL served as the controls.

Comparative Effectiveness of Prophylactic Strategies for Perinatal Transmission of Hepatitis B Virus: A Network Meta-analysis of Randomized Controlled Trials.

Background: Perinatal transmission is the main route of hepatitis B virus (HBV) transmission. While several measures have been attempted as means of preventing perinatal HBV transmission, the optimal strategy remains inconclusive.

Methods: We conducted a comprehensive search, through December 2016, for randomized controlled trials (RCTs) that compared the following measures among pregnant women with HBV infection: placebo/none, active immunoprophylaxis (hepatitis B vaccine series starting at birth [HBVac]), passive-active immunoprophylaxis (hepatitis B immunoglobulin and vaccine [HBIG+HBVac]), prenatal HBIG administration (HBIG/HBIG+HBVac), and prenatal antiviral therapy (AVT/HBIG+HBVac).

Graphene oxide hydrogel as a restricted-area nanoreactor for synthesis of 3D graphene-supported ultrafine TiO nanorod nanocomposites for high-rate lithium-ion battery anodes.

Three-dimensional graphene-supported TiO nanorod nanocomposites (3D GS-TNR) are prepared using graphene oxide hydrogel as a restricted-area nanoreactor in the hydrothermal process, in which well-distributed TiO nanorods with a width of approximately 5 nm and length of 30 nm are conformally embedded in the 3D interconnected graphene network. The 3D graphene oxide not only works as a restricted-area nanoreactor to constrain the size, distribution and morphology of the TiO; it also work as a highly interconnected conducting network to facilitate electrochemical reactions and maintain good structural integration when the nanocomposites are used as anode materials in lithium-ion batteries. Benefiting from the nanostructure, the 3D GS-TNR nanocomposites show high capacity and excellent long-term cycling capability at high current rates.

Clinical course and perinatal transmission of chronic hepatitis B during pregnancy: A real-world prospective cohort study.

Objective: To determine the clinical course and perinatal transmission of chronic hepatitis B during pregnancy in a real life setting.

Methods: A total of 221 singleton pregnant women with detectable HBV-DNA levels (≥10 copies/mL) were enrolled during January 2011 to June 2015. Forty-three high viraemic patients (≥10 copies/mL) received telbivudine in the 2 or 3 trimester according to their intention, while 89 high viraemic and 79 low viraemic (≥10 and <10 copies/mL) patients were the control cohorts.

Overexpression of ARF1 is associated with cell proliferation and migration through PI3K signal pathway in ovarian cancer.

ADP-ribosylation factor 1 (ARF1) is a small G protein that regulates many cellular processes such as reorganization of the actin cytoskeleton and is highly expressed in various tumor cells and tissues. However, the role of ARF1 in ovarian cancer progression remains unknown. In the present study, we explored the expression patterns of ARF1 in clinical ovarian cancer samples and adjacent noncancerous tissues.

Needle-like Co3O4 anchored on the graphene with enhanced electrochemical performance for aqueous supercapacitors.

We synthesized the needle-like cobalt oxide/graphene composites with different mass ratios, which are composed of cobalt oxide (Co3O4 or CoO) needle homogeneously anchored on graphene nanosheets as the template, by a facile hydrothermal method. Without the graphene as the template, the cobalt precursor tends to group into urchin-like spheres formed by many fine needles. When used as electrode materials of aqueous supercapacitor, the composites of the needle-like Co3O4/graphene (the mass ratio of graphene oxide(GO) and Co(NO3)2·6H2O is 1:5) exhibit a high specific capacitance of 157.

Hierarchical foam of exposed ultrathin nickel nanosheets supported on chainlike Ni-nanowires and the derivative chalcogenide for enhanced pseudocapacitance.

Foamlike nickel hierarchical structures of ultrathin nanosheets supported on thin wires composed of nanoparticles are prepared by a facile one-pot synthesis via controlled nucleation and growth process. By further sulfidation, the sulfide derivative of loose porous fibrous structure shows a high electrochemical capacity for potential pseudocapacitor applications.