Publications by authors named "Guido Siccardi"
Article Synopsis
- The study analyzed clinical characteristics and mortality risk factors for COVID-19 patients in an Italian hospital from March to May 2020, involving 258 patients with a mortality rate of 13.2%.
- Key findings included that most patients were middle-aged (median age 62), with common symptoms like fever and cough, and a significant number had underlying health issues (66.7%).
- Factors associated with higher mortality included older age, being male, high blood urea levels, and a decreased PaO2/FiO2 ratio, indicating severity in respiratory distress.
Background: Little is known on the burden of co-infections and superinfections in a specific setting such as the respiratory COVID-19 sub-intensive care unit. This study aims to (i) assess the prevalence of concurrent and superinfections in a respiratory sub-intensive care unit, (ii) evaluate the risk factors for superinfections development and (iii) assess the impact of superinfections on in-hospital mortality.
Methods: Single-center retrospective analysis of prospectively collected data including COVID-19 patients hospitalized in a newly established respiratory sub-intensive care unit managed by pneumologists which has been set up from September 2020 at a large (1200 beds) University Hospital in Rome.
Convalescent plasma (CP) therapy might be effective in patients with haematological malignanciesand B-cell depletion. We report a single-centre experience of COVID-19 patients with non-Hodgkinlymphoma and absence of B-cells as a consequence of anti-CD20 therapy successfully treated withCP from October 2020 to May 2021. CP was given in the presence of pneumonia with respiratoryfailure despite standard treatment and consisted of three infusions on an alternate-day basis.
View Article and Find Full Text PDFIncreased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia.
Front Immunol
April 2021
Background: Emerging evidence argues that monocytes, circulating innate immune cells, are principal players in COVID-19 pneumonia. The study aimed to investigate the role of soluble (s)CD163 and sCD14 plasmatic levels in predicting disease severity and characterize peripheral blood monocytes and dendritic cells (DCs), in patients with COVID-19 pneumonia (COVID-19 subjects).
Methods: On admission, in COVID-19 subjects sCD163 and sCD14 plasmatic levels, and peripheral blood monocyte and DC subsets were compared to healthy donors (HDs).
To evaluate the efficacy, safety, and tolerability of switching to a dolutegravir (DTG)-based regimen in a cohort of virological suppressed HIV-infected patients who have previously been treated with different antiretroviral combination. The dynamics of total HIV-DNA and levels of high-sensitivity c-reactive protein, interleukin-6, soluble-CD14, and D-Dimer were also analyzed. Ninety-six individuals who switched to a DTG-containing regimen were followed up for 48 weeks.
View Article and Find Full Text PDFArticle Synopsis
- Invasive pulmonary aspergillosis (IPA) is increasingly being observed in patients without typical immunocompromised conditions, prompting a need for better risk assessment.
- The study aimed to create a predictive model for IPA in influenza patients using machine learning techniques, specifically decision trees.
- Among 77 hospitalized influenza patients, five cases of IPA were identified, indicating that those with lymphocytopenia or who received corticosteroid therapy are notably more at risk.
Article Synopsis
- A study compares the immune responses of a 52-year-old woman infected with both SARS-CoV-2 and HIV-1 to those of HIV-1-positive and uninfected women.
- Severe pneumonia was noted in the coinfected patient during the second week of her illness, confirmed by chest imaging showing bilateral ground-glass opacities.
- After a 7-day treatment with hydroxychloroquine, the patient showed significant improvement, including resolved fever and normalized respiratory rate.